Recombinant Human Histone Deacetylase 1, GST-tagged

• Cat.No.: HDAC1-1587H
• Product Overview: Full-length recombinant human HDAC1 was expressed by baculovirus in Sf9 insect cells using a C-terminal GST tag.

Specification

• Cat. No.: HDAC1-1587H
• Description: HDAC1 or Histone deacetylase 1 belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex which plays a key role in the regulation of eukaryotic gene expression. HDAC1 interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, HDAC1 deacetylates p53 and modulates its effect on cell growth and apoptosis.
• Applications: HDAC Assay; Western Blot
• Molecular Weight: 88 kDa
• Expression System: Sf9 insect cells using baculovirus
• Species: Human
• Form: Recombinant protein stored in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.
• Purity: >70%
• Concentration: 0.1 ug/ul
• Specific Activity: 8900 RLU/min/ng
• Sequences: Full length
• Storage: Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
• Pathways: Chronic myeloid leukemia; Delta-Notch Signaling Pathway; Delta-Notch Signaling Pathway; E2F transcription factor network; EGFR1 Signaling Pathway; Energy Metabolism; Hemostasis; Huntington"s disease; IL-6 Signaling Pathway; Pathways in cancer; Pathways in cancer; Regulation of Telomerase; Signalling by NGF; Signalling by NGF; TNF-alpha/NF-kB Signaling Pathway

Gene Information

• Gene Name: HDAC1 histone deacetylase 1 [ Homo sapiens ]
• Official Symbol: HDAC1
• Synonyms: HDAC1; histone deacetylase 1; HD1; RPD3; GON-10; RPD3L1; DKFZp686H12203; histone deacetylase 1; OTTHUMP00000008745; reduced potassium dependency, yeast homolog-like 1
• Gene ID: 3065
• mRNA Refseq: NM_004964
• Protein Refseq: NP_004955
• MIM: 601241
• UniProt ID: Q13547
• Chromosome Location: 1p34
• Function: NAD-dependent histone deacetylase activity (H3-K14 specific); NAD-dependent histone deacetylase activity (H3-K9 specific); RNA polymerase II transcription corepressor activity; RNA polymerase II transcription corepressor activity; activating transcription factor binding; enzyme binding; histone deacetylase activity; histone deacetylase activity (H3-K16 specific); histone deacetylase binding; hydrolase activity; protein binding; sequence-specific DNA binding transcription factor activity; transcription factor binding