| Cat. No.: | MAPK3-1048H |
| Product Overview: | Recombinant full-length human MAPK3 was expressed in E.coli using an N-terminal GST tag. |
| Description: | MAPK3 is a protein serine/threonine kinase that is a member of the extracellular signal-regulated kinases (ERKs) which are activated in response to numerous growth factors and cytokines. Activation of MAPK3 requires both tyrosine and threonine phosphorylation that is mediated by MEK. MAPK3 is ubiquitously distributed in tissues with the highest expression in heart, brain and spinal cord. Activated MAPK3 translocates into the nucleus where it phosphorylates various transcription factors (e.g., Elk-1, c-Myc, c-Jun, c-Fos, and C/EBP beta). |
| Applications: | Kinase Assay, Western Blot |
| Molecular Weight: | 72 kDa |
| Expression System: | E. coli |
| Species: | Human |
| Form: | Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol. |
| Specific Activity: | 840 nmol/min/mg |
| Purity: | > 90 % |
| Concentration: | 0.1 ug/ul |
| Sequences: | Full-length |
| Storage: | Store product at -70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
| Pathways: | Acute myeloid leukemia; Adherens junction; Alzheimer"s disease; Alzheimer"s disease; B cell receptor signaling pathway; Bladder cancer; Chronic myeloid leukemia; Chemokine signaling pathway; Colorectal cancer; Dorso-ventral axis formation; Endometrial cancer; ErbB signaling pathway; Fc epsilon RI signaling pathway; Fc gamma R-mediated phagocytosis; Gap junction; Glioma; GnRH signaling pathway; Insulin signaling pathway; Long-term potentiation; Long-term depression; MAPK signaling pathway; Melanogenesis |
| Gene Name: | MAPK3 mitogen-activated protein kinase 3 [ Homo sapiens ] |
| Official Symbol: | MAPK3 |
| Synonyms: | MAPK3; mitogen-activated protein kinase 3; ERK1; PRKM3; P44ERK1; P44MAPK; HS44KDAP; HUMKER1A; MGC20180; EC 2.7.11.24; Extracellular signal-regulated kinase 1; Insulin-stimulated MAP2 kinase; MAP kinase 1; Microtubule-associated protein 2 kinas; OTTHUMP00000174538; OTTHUMP00000174540; Microtubule-associated protein 2 kinase; mitogen-activated protein kinase 3 |
| Gene ID: | 5595 |
| mRNA Refseq: | NM_002746 |
| Protein Refseq: | NP_002737 |
| MIM: | 601795 |
| UniProt ID: | P27361 |
| Chromosome Location: | 16p11.2 |
| Function: | ATP binding; MAP kinase activity; nucleotide binding; protein binding; protein serine/threonine kinase activity; transferase activity |
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