Recombinant Human Maternal Embryonic Leucine Zipper Kinase, GST-tagged
| Cat.No. : | MELK-1059H |
| Product Overview : | Recombinant human MELK (1-340) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. |
- Specification
- Gene Information
- Related Products
| Cat. No. : | MELK-1059H |
| Description : | MELK or maternal embryonic leucine zipper kinase is a member of the CAMKL kinase family. MELK is a key regulator of the proliferation of malignant brain tumors including their stem cells (1). MELK transcript abundance correlates with malignancy grade in human astrocytomas and represents a therapeutic target for the management of the most frequent brain tumors in adult and children. MELK also plays a role in mammary carcinogenesis through inhibition of the pro-apoptotic function of Bcl-GL (2). Therefore, the kinase activity of MELK could be a promising molecular target for development of therapy for patients with breast cancers. |
| Applications : | Kinase Assay; Western Blot |
| Molecular Weight : | 61 kDa |
| Expression System : | Sf9 insect cells using baculovirus |
| Species : | Human |
| Form : | Recombinant protein stored in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol |
| Specific Activity : | 200 nmol/min/mg |
| Purity : | > 85% |
| Concentration : | 0.1 ug/ul |
| Sequences : | 1-340 |
| Storage : | Store product at -70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
| Gene Name : | MELK maternal embryonic leucine zipper kinase [ Homo sapiens ] |
| Official Symbol : | MELK |
| Synonyms : | MELK; maternal embryonic leucine zipper kinase; HPK38; KIAA0175; Hmelk; pEg3 kinase; protein kinase PK38; EC 2.7.11.1; Protein kinase PK38 |
| Gene ID : | 9833 |
| mRNA Refseq : | NM_014791 |
| Protein Refseq : | NP_055606 |
| MIM : | 607025 |
| UniProt ID : | Q14680 |
| Chromosome Location : | 9p13.2 |
| Function : | ATP binding; nucleotide binding; protein binding; protein serine/threonine kinase activity; transferase activity |
Products Types
| ◆ Recombinant Protein | ||
| MELK-1134H | Recombinant Human MELK Protein (D3-V330), Tag Free | +Inquiry |
| MELK-4447H | Recombinant Human MELK Protein, GST-tagged | +Inquiry |
| MELK-4448H | Active Recombinant Human MELK Protein, GST-tagged | +Inquiry |
| MELK-1135H | Recombinant Human MELK Protein (D3-V330), His tagged | +Inquiry |
| MELK-5473M | Recombinant Mouse MELK Protein, His (Fc)-Avi-tagged | +Inquiry |
| ◆ Lysates | ||
| MELK-4368HCL | Recombinant Human MELK 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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