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| Cat. No.: | MELK-1059H |
| Product Overview: | Recombinant human MELK (1-340) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. |
| Description: | MELK or maternal embryonic leucine zipper kinase is a member of the CAMKL kinase family. MELK is a key regulator of the proliferation of malignant brain tumors including their stem cells (1). MELK transcript abundance correlates with malignancy grade in human astrocytomas and represents a therapeutic target for the management of the most frequent brain tumors in adult and children. MELK also plays a role in mammary carcinogenesis through inhibition of the pro-apoptotic function of Bcl-GL (2). Therefore, the kinase activity of MELK could be a promising molecular target for development of therapy for patients with breast cancers. |
| Applications: | Kinase Assay; Western Blot |
| Molecular Weight: | 61 kDa |
| Expression System: | Sf9 insect cells using baculovirus |
| Species: | Human |
| Form: | Recombinant protein stored in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol |
| Specific Activity: | 200 nmol/min/mg |
| Purity: | > 85% |
| Concentration: | 0.1 ug/ul |
| Sequences: | 1-340 |
| Storage: | Store product at -70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
| Gene Name: | MELK maternal embryonic leucine zipper kinase [ Homo sapiens ] |
| Official Symbol: | MELK |
| Synonyms: | MELK; maternal embryonic leucine zipper kinase; HPK38; KIAA0175; Hmelk; pEg3 kinase; protein kinase PK38; EC 2.7.11.1; Protein kinase PK38 |
| Gene ID: | 9833 |
| mRNA Refseq: | NM_014791 |
| Protein Refseq: | NP_055606 |
| MIM: | 607025 |
| UniProt ID: | Q14680 |
| Chromosome Location: | 9p13.2 |
| Function: | ATP binding; nucleotide binding; protein binding; protein serine/threonine kinase activity; transferase activity |
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