"MELK" Related Products

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Recombinant Human Maternal Embryonic Leucine Zipper Kinase, GST-tagged

Cat. No.: MELK-1059H
Product Overview: Recombinant human MELK (1-340) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Description: MELK or maternal embryonic leucine zipper kinase is a member of the CAMKL kinase family. MELK is a key regulator of the proliferation of malignant brain tumors including their stem cells (1). MELK transcript abundance correlates with malignancy grade in human astrocytomas and represents a therapeutic target for the management of the most frequent brain tumors in adult and children. MELK also plays a role in mammary carcinogenesis through inhibition of the pro-apoptotic function of Bcl-GL (2). Therefore, the kinase activity of MELK could be a promising molecular target for development of therapy for patients with breast cancers.
Applications: Kinase Assay; Western Blot
Molecular Weight: 61 kDa
Expression System: Sf9 insect cells using baculovirus
Species: Human
Form: Recombinant protein stored in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol
Specific Activity: 200 nmol/min/mg
Purity: > 85%
Concentration: 0.1 ug/ul
Sequences: 1-340
Storage: Store product at -70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Gene Name: MELK maternal embryonic leucine zipper kinase [ Homo sapiens ]
Official Symbol: MELK
Synonyms: MELK; maternal embryonic leucine zipper kinase; HPK38; KIAA0175; Hmelk; pEg3 kinase; protein kinase PK38; EC 2.7.11.1; Protein kinase PK38
Gene ID: 9833
mRNA Refseq: NM_014791
Protein Refseq: NP_055606
MIM: 607025
UniProt ID: Q14680
Chromosome Location: 9p13.2
Function: ATP binding; nucleotide binding; protein binding; protein serine/threonine kinase activity; transferase activity

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