Recombinant Human PCNA protein, His-tagged
Cat.No. : | PCNA-4863 |
Product Overview : | Recombinant Human PCNA fussed with His tag at N-terminal was expressed in E. coli. |
- Specification
- Gene Information
- Related Products
Source : | E. coli |
Species : | Human |
Tag : | His |
Form : | 50mM sodium phosphate, pH 7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.25mM DTT, 25% glycerol. |
Molecular Mass : | ~37 kDa |
Protein length : | Full Length |
Purity : | >90 % |
Applications : | Western Blot |
Stability : | 1 yr at -70 centigrade from date of shipment |
Storage : | Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
Concentration : | 0.2 ug/ul |
Shipping : | Product shipped on dry ice |
Gene Name : | PCNA proliferating cell nuclear antigen [ Homo sapiens ] |
Official Symbol : | PCNA |
Synonyms : | PCNA; proliferating cell nuclear antigen; cyclin; DNA polymerase delta auxiliary protein; MGC8367; |
Gene ID : | 5111 |
mRNA Refseq : | NM_002592 |
Protein Refseq : | NP_002583 |
MIM : | 176740 |
UniProt ID : | P12004 |
Chromosome Location : | 20pter-p12 |
Pathway : | BARD1 signaling events, organism-specific biosystem; BRCA1-associated genome surveillance complex (BASC), organism-specific biosystem; Base Excision Repair, organism-specific biosystem; Base excision repair, organism-specific biosystem; Base excision repair, conserved biosystem; Cell Cycle, organism-specific biosystem; Cell Cycle, Mitotic, organism-specific biosystem; |
Function : | DNA binding; DNA polymerase processivity factor activity; MutLalpha complex binding; dinucleotide insertion or deletion binding; identical protein binding; protein binding; purine-specific mismatch base pair DNA N-glycosylase activity; receptor tyrosine k |
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◆ Lysates | ||
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Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionYes, elevated PCNA levels in tumor tissues are associated with a poorer prognosis in many cancer types.
Mutations in the PCNA gene can lead to DNA repair deficiencies and may be associated with increased cancer risk and poor clinical outcomes.
PCNA is often overexpressed in cancer cells, making it a potential diagnostic marker and a target for cancer therapies.
Yes, some clinical trials are exploring drugs that target PCNA, primarily in the context of cancer treatment.
PCNA acts as a scaffold for various DNA repair proteins, making it crucial for maintaining genomic stability and relevant in DNA repair-based therapies.
Customer Reviews (3)
Write a reviewIn protein electron microscopy structure analysis, PCNA protein proved to be an invaluable tool, allowing for the precise determination of protein structures with remarkable clarity and resolution.
In my ELISA experiments, PCNA protein consistently provided reliable and reproducible results, with high sensitivity and specificity.
I enthusiastically endorse PCNA protein as it delivers exceptional performance in a wide range of applications.
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