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Recombinant Human PCNA protein, His-tagged

Cat.No. : PCNA-4863
Product Overview : Recombinant Human PCNA fussed with His tag at N-terminal was expressed in E. coli.
  • Specification
  • Gene Information
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Source : E. coli
Species : Human
Tag : His
Form : 50mM sodium phosphate, pH 7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.25mM DTT, 25% glycerol.
Molecular Mass : ~37 kDa
Protein length : Full Length
Purity : >90 %
Applications : Western Blot
Stability : 1 yr at -70 centigrade from date of shipment
Storage : Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Concentration : 0.2 ug/ul
Shipping : Product shipped on dry ice
Gene Name : PCNA proliferating cell nuclear antigen [ Homo sapiens ]
Official Symbol : PCNA
Synonyms : PCNA; proliferating cell nuclear antigen; cyclin; DNA polymerase delta auxiliary protein; MGC8367;
Gene ID : 5111
mRNA Refseq : NM_002592
Protein Refseq : NP_002583
MIM : 176740
UniProt ID : P12004
Chromosome Location : 20pter-p12
Pathway : BARD1 signaling events, organism-specific biosystem; BRCA1-associated genome surveillance complex (BASC), organism-specific biosystem; Base Excision Repair, organism-specific biosystem; Base excision repair, organism-specific biosystem; Base excision repair, conserved biosystem; Cell Cycle, organism-specific biosystem; Cell Cycle, Mitotic, organism-specific biosystem;
Function : DNA binding; DNA polymerase processivity factor activity; MutLalpha complex binding; dinucleotide insertion or deletion binding; identical protein binding; protein binding; purine-specific mismatch base pair DNA N-glycosylase activity; receptor tyrosine k

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Can PCNA levels in tumor tissues provide prognostic information for cancer patients? 05/18/2021

Yes, elevated PCNA levels in tumor tissues are associated with a poorer prognosis in many cancer types.

Are there any genetic mutations associated with PCNA that impact clinical outcomes? 04/12/2021

Mutations in the PCNA gene can lead to DNA repair deficiencies and may be associated with increased cancer risk and poor clinical outcomes.

How is PCNA protein relevant in cancer diagnosis and treatment? 03/01/2020

PCNA is often overexpressed in cancer cells, making it a potential diagnostic marker and a target for cancer therapies.

Are there any PCNA-targeted therapies currently in clinical trials or use? 03/02/2018

Yes, some clinical trials are exploring drugs that target PCNA, primarily in the context of cancer treatment.

How is PCNA protein involved in DNA repair pathways, and how is this relevant to clinical applications 01/15/2016

PCNA acts as a scaffold for various DNA repair proteins, making it crucial for maintaining genomic stability and relevant in DNA repair-based therapies.

Customer Reviews (3)

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Reviews
01/04/2023

    In protein electron microscopy structure analysis, PCNA protein proved to be an invaluable tool, allowing for the precise determination of protein structures with remarkable clarity and resolution.

    06/17/2017

      In my ELISA experiments, PCNA protein consistently provided reliable and reproducible results, with high sensitivity and specificity.

      04/07/2016

        I enthusiastically endorse PCNA protein as it delivers exceptional performance in a wide range of applications.

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