Recombinant Yeast PCNA protein

• Cat.No.: PCNA-1534Y
• Product Overview: Recombinant full length protein was expressed in E. coli.

Specification

• Description: PCNA is a replication accessory factor and is also involved in DNA repair. During replication, PCNA acts as a processivity factor of DNA polymerases δ and ε. In DNA repair, PCNA is required for nucleotide excision repair, is involved in the long patch base excision repair, and is critical in error-free post replication repair, as well as translesion DNA synthesis. Loading of PCNA onto DNA may require RFC and RPA.
• Source: E. coli
• Species: Yeast
• Form: 50 mM Tris-HCl (pH7.5), 600 mM NaCl, and 10% glycerol.
• Molecular Mass: 29 kDa
• Usage: Suggested dilution buffer (not included): 50 mM Tris-HCl (pH 7.5), 5 mM β-mercaptoethanol, 50% glycerol.
• Storage: Stable for 2 years at -70 centigrade from date of shipment. Please aliquot to avoid repeated freezing and thawing.
• Official Symbol: PCNA

Gene Information

• Official Symbol: PCNA

Reviews

01/04/2023

In protein electron microscopy structure analysis, PCNA protein proved to be an invaluable tool, allowing for the precise determination of protein structures with remarkable clarity and resolution.

06/17/2017

In my ELISA experiments, PCNA protein consistently provided reliable and reproducible results, with high sensitivity and specificity.

04/07/2016

I enthusiastically endorse PCNA protein as it delivers exceptional performance in a wide range of applications.

Q&As

Can PCNA levels in tumor tissues provide prognostic information for cancer patients?

Yes, elevated PCNA levels in tumor tissues are associated with a poorer prognosis in many cancer types.

Are there any genetic mutations associated with PCNA that impact clinical outcomes?

Mutations in the PCNA gene can lead to DNA repair deficiencies and may be associated with increased cancer risk and poor clinical outcomes.

How is PCNA protein relevant in cancer diagnosis and treatment?

PCNA is often overexpressed in cancer cells, making it a potential diagnostic marker and a target for cancer therapies.

Are there any PCNA-targeted therapies currently in clinical trials or use?

Yes, some clinical trials are exploring drugs that target PCNA, primarily in the context of cancer treatment.

How is PCNA protein involved in DNA repair pathways, and how is this relevant to clinical applications

PCNA acts as a scaffold for various DNA repair proteins, making it crucial for maintaining genomic stability and relevant in DNA repair-based therapies.