Human Alpha-Fetoprotein
Cat.No. : | AFP-4769H |
Product Overview : | This antigen is ideal for labeling or immunization purposes. |
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- Gene Information
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Cat. No. : | AFP-4769H |
Description : | Alpha-fetoprotein (AFP, α-fetoprotein; also sometimes called alpha-1-fetoprotein or alpha-fetoglobulin) is a protein that in humans is encoded by the AFP gene. AFP is a major plasma protein produced by the yolk sac and the liver during fetal development that is thought to be the fetal form of serum albumin. The AFP gene is located on the q arm of chromosome 4 (4q25). AFP binds to copper, nickel, fatty acids and bilirubin and is found in monomeric, dimeric and trimeric forms. |
Source : | Human cord serum |
Species : | Human |
Form : | Liquid. The antigen is in 0.1M Sodium Phosphate buffer, 0.2M NaCl, pH 7.4, with 0.1% sodium azide as preservative. |
Contaminants : | None detected by reduced and non-reduced SDS-PAGE. |
Purity : | >98% By SDS PAGE |
Concentration : | 2.3 mg/ml |
Biohazard : | Raw material tested at the donor level by approved FDA methods and found to be negative for anti-HCV, anti-HIV-1 and 2, and HBsAg. |
Storage : | Store between 2-8°C. for short term. For long-term storage, aliquot and freeze at -20°C. |
Gene Name : | AFP alpha-fetoprotein [ Homo sapiens ] |
Official Symbol : | AFP |
Synonyms : | AFP; alpha-fetoprotein; FETA; HPAFP; OTTHUMP00000160480; OTTHUMP00000220440; alpha-fetoglobulin; alpha-1-fetoprotein |
Gene ID : | 174 |
mRNA Refseq : | NM_001134 |
Protein Refseq : | NP_001125 |
MIM : | 104150 |
UniProt ID : | P02771 |
Chromosome Location : | 4q11-q13 |
Pathway : | Direct p53 effectors; FOXA2 and FOXA3 transcription factor networks; Glucocorticoid receptor regulatory network |
Function : | metal ion binding |
Products Types
◆ Recombinant Protein | ||
AFP-379M | Recombinant Mouse AFP Protein, His (Fc)-Avi-tagged | +Inquiry |
AFP-0004H | Recombinant Human AFP Protein | +Inquiry |
AFP-289H | Recombinant Human AFP Protein, His (Fc)-Avi-tagged | +Inquiry |
AFP-1059H | Recombinant Human AFP Protein (Met1-Val609), HlgG1 Fc-tagged | +Inquiry |
AFP-52H | Recombinant Human AFP Protein, His-tagged | +Inquiry |
◆ Native Protein | ||
AFP-3017H | Native Human fetal cord serum | +Inquiry |
AFP-3018P | Native pig AFP | +Inquiry |
AFP-8027H | Native Human Alpha FetoProtein | +Inquiry |
◆ Lysates | ||
AFP-1706HCL | Recombinant Human AFP cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a questionThe clinical utility of AFP protein as a diagnostic or prognostic marker can be validated through clinical studies using patient samples, correlation analyses with disease outcomes, or comparison with existing diagnostic methods.
Downstream signaling pathways or cellular responses triggered by AFP protein binding or activation can be studied using techniques such as Western blotting, gene expression analysis, or functional assays specific to the signaling pathways of interest.
Therapeutic interventions or treatment strategies targeting AFP protein can be evaluated for efficacy and safety using in vitro or in vivo models, disease-specific assays, or clinical trials to assess their impact on disease progression, patient outcomes, or potential side effects.
The cellular and molecular mechanisms underlying the production and secretion of AFP protein can be elucidated through techniques such as gene expression analysis, protein trafficking studies, or immunofluorescence microscopy.
Genetic variations or mutations in the AFP gene that impact its expression or function can be investigated through genetic association studies, functional characterization of mutant variants, or population-based analyses.
The regulatory factors or signaling pathways that control the expression and transcriptional regulation of the AFP gene can be studied using techniques such as promoter analysis, transcription factor binding assays, or gene knockout/knockdown approaches.
The functional roles of AFP protein in embryonic development, tissue regeneration, or disease progression can be investigated through genetic or pharmacological perturbations, in vitro or in vivo model systems, or functional assays specific to the biological processes of interest.
Specific biomarkers or imaging techniques for detecting AFP protein in biological samples can be developed and their sensitivity and specificity can be assessed using techniques such as ELISA, immunohistochemistry, or imaging modalities like MRI or PET.
The interactions of AFP protein with its binding partners or ligands can be studied using techniques such as co-immunoprecipitation, surface plasmon resonance, or receptor-binding assays.
The immune-related functions of AFP protein, such as immunomodulation or immune evasion, can be investigated using techniques like immune cell assays, cytokine profiling, or immune response assays.
Customer Reviews (3)
Write a reviewInvestigating protein-protein interactions in cellular stress responses for cell survival.
Dissecting protein-protein interactions in viral replication for antiviral strategies.
Mapping protein-protein interactions in protein degradation pathways for proteostasis.
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