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Human Alpha-Fetoprotein

Cat.No. : AFP-4769H
Product Overview : This antigen is ideal for labeling or immunization purposes.
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  • Gene Information
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Cat. No. : AFP-4769H
Description : Alpha-fetoprotein (AFP, α-fetoprotein; also sometimes called alpha-1-fetoprotein or alpha-fetoglobulin) is a protein that in humans is encoded by the AFP gene. AFP is a major plasma protein produced by the yolk sac and the liver during fetal development that is thought to be the fetal form of serum albumin. The AFP gene is located on the q arm of chromosome 4 (4q25). AFP binds to copper, nickel, fatty acids and bilirubin and is found in monomeric, dimeric and trimeric forms.
Source : Human cord serum
Species : Human
Form : Liquid. The antigen is in 0.1M Sodium Phosphate buffer, 0.2M NaCl, pH 7.4, with 0.1% sodium azide as preservative.
Contaminants : None detected by reduced and non-reduced SDS-PAGE.
Purity : >98% By SDS PAGE
Concentration : 2.3 mg/ml
Biohazard : Raw material tested at the donor level by approved FDA methods and found to be negative for anti-HCV, anti-HIV-1 and 2, and HBsAg.
Storage : Store between 2-8°C. for short term. For long-term storage, aliquot and freeze at -20°C.
Gene Name : AFP alpha-fetoprotein [ Homo sapiens ]
Official Symbol : AFP
Synonyms : AFP; alpha-fetoprotein; FETA; HPAFP; OTTHUMP00000160480; OTTHUMP00000220440; alpha-fetoglobulin; alpha-1-fetoprotein
Gene ID : 174
mRNA Refseq : NM_001134
Protein Refseq : NP_001125
MIM : 104150
UniProt ID : P02771
Chromosome Location : 4q11-q13
Pathway : Direct p53 effectors; FOXA2 and FOXA3 transcription factor networks; Glucocorticoid receptor regulatory network
Function : metal ion binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (10)

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Can AFP protein be utilized as a diagnostic or prognostic marker for certain diseases or conditions, and what experimental studies can be conducted to validate its clinical utility? 09/09/2022

The clinical utility of AFP protein as a diagnostic or prognostic marker can be validated through clinical studies using patient samples, correlation analyses with disease outcomes, or comparison with existing diagnostic methods.

What are the downstream signaling pathways or cellular responses triggered by AFP protein binding or activation, and how can they be studied using molecular and cellular techniques? 08/02/2022

Downstream signaling pathways or cellular responses triggered by AFP protein binding or activation can be studied using techniques such as Western blotting, gene expression analysis, or functional assays specific to the signaling pathways of interest.

Can AFP protein be targeted or manipulated to develop therapeutic interventions or treatment strategies, and what experimental approaches can be used to evaluate their efficacy and safety? 12/29/2021

Therapeutic interventions or treatment strategies targeting AFP protein can be evaluated for efficacy and safety using in vitro or in vivo models, disease-specific assays, or clinical trials to assess their impact on disease progression, patient outcomes, or potential side effects.

What are the cellular and molecular mechanisms underlying the production and secretion of AFP protein, and how can they be experimentally elucidated? 03/28/2021

The cellular and molecular mechanisms underlying the production and secretion of AFP protein can be elucidated through techniques such as gene expression analysis, protein trafficking studies, or immunofluorescence microscopy.

Are there any genetic variations or mutations in the AFP gene that impact its expression or function, and what are the implications for disease susceptibility or clinical outcomes? 07/22/2018

Genetic variations or mutations in the AFP gene that impact its expression or function can be investigated through genetic association studies, functional characterization of mutant variants, or population-based analyses.

What are the regulatory factors or signaling pathways that control the expression and transcriptional regulation of AFP gene, and how can their involvement be studied? 12/19/2017

The regulatory factors or signaling pathways that control the expression and transcriptional regulation of the AFP gene can be studied using techniques such as promoter analysis, transcription factor binding assays, or gene knockout/knockdown approaches.

What are the functional roles of AFP protein in embryonic development, tissue regeneration, or disease progression, and how can its biological functions be investigated experimentally? 04/30/2017

The functional roles of AFP protein in embryonic development, tissue regeneration, or disease progression can be investigated through genetic or pharmacological perturbations, in vitro or in vivo model systems, or functional assays specific to the biological processes of interest.

Are there any specific biomarkers or imaging techniques that can be used to detect AFP protein in biological samples, and how can their sensitivity and specificity be assessed experimentally? 09/21/2016

Specific biomarkers or imaging techniques for detecting AFP protein in biological samples can be developed and their sensitivity and specificity can be assessed using techniques such as ELISA, immunohistochemistry, or imaging modalities like MRI or PET.

How does AFP protein interact with its binding partners or ligands, and what experimental approaches can be used to study these interactions? 10/05/2015

The interactions of AFP protein with its binding partners or ligands can be studied using techniques such as co-immunoprecipitation, surface plasmon resonance, or receptor-binding assays.

How does AFP protein contribute to immunomodulation or immune evasion, and what experimental strategies can be employed to investigate its immune-related functions? 05/24/2015

The immune-related functions of AFP protein, such as immunomodulation or immune evasion, can be investigated using techniques like immune cell assays, cytokine profiling, or immune response assays.

Customer Reviews (3)

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Reviews
11/14/2022

    Investigating protein-protein interactions in cellular stress responses for cell survival.

    02/15/2020

      Dissecting protein-protein interactions in viral replication for antiviral strategies.

      03/09/2017

        Mapping protein-protein interactions in protein degradation pathways for proteostasis.

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