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| Cat. No.: | TNFRSF9-43H |
| Product Overview: | Recombinant Human TNFRSF9, Fc-tagged expressed in human cells is a disulfide-linked homodimeric protein. The reduced monomer consists of 409 amino acids and has a calculated molecular mass of 45.2 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rh4-1BB/Fc monomer is approximately 60-65 kDa due to glycosylation |
| Description: | 4-1BB is an inducible T cell surface protein belonging to the TNF receptor superfamily. It is alternatively known as TNFRSF9, CD137, and ILA. The 255 amino acid human 4-1BB is a type I transmembrane protein having in its extracellular domain four of the cysteine-rich motifs that are characteristic of the TNF receptor superfamily. The 30 KD glycoprotein exists both as a monomer and as a dimer on T cells. The human and mouse proteins share 60% amino acid identity.A DNA sequence encoding the N-terminal fragment (Met 1– Gln 186) of the extracellular domain of human 4-1BB (NP_001552.2) was fused with the C-terminal polyhistidine-tagged Fc region of human IgG1 at the C-terminus. |
| Purity: | > 97%, as determined by SDS-PAGE and SEC-HPLC Analysis |
| Predicted N terminal: | Gln 25 |
| Endotoxin: | < 1.0 EU per 1 μg of the cytokine as determined by the LAL method |
| Formulation: | Supplied as a 0.2μm filtered solution of PBS, pH7.4 |
| Reconstitution: | Follow the instructions on the vial. Centrifuge the vial at 4°Cbefore opening to recover the entire contents. |
| Stability: | Samples are stable for up to twelve months from date of receipt -70C |
| Storage: | Store at –70°C; Avoid repeated freeze-thaw cycles |
| Gene Name: | TNFRSF9 |
| Synonyms: | 4-1BB; CD137; CDw137; ILA; MGC2172; 4-1BB ligand receptor; CD137 antigen; OTTHUMP00000001360; OTTHUMP00000044294; T cell antigen ILA; homolog of mouse 4-1BB; induced by lymphocyte activation (ILA); interleukin-activated receptor, homolog of mouse Ly63; receptor protein 4-1BB; TNFRSF9; tumor necrosis factor receptor superfamily, member 9 |
| Gene ID: | 3604 |
| mRNA Refseq: | NM_001561 |
| Protein Refseq: | NP_001552 |
| MIM: | 602250 |
| UniProt ID: | Q07011 |
| Chromosome Location: | 1p36 |
| Pathway: | Cytokine-cytokine receptor interaction |
| Function: | induction of apoptosis; negative regulation of cell proliferase |
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