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Recombinant Human TNFRSF9, Fc-tagged
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Cat.No. : | TNFRSF9-43H Optional Service: Optional requirements on this protein |
Product Overview : | Recombinant Human TNFRSF9, Fc-tagged expressed in human cells is a disulfide-linked homodimeric protein. The reduced monomer consists of 409 amino acids and has a calculated molecular mass of 45.2 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rh4-1BB/Fc monomer is approximately 60-65 kDa due to glycosylation |
Description : | 4-1BB is an inducible T cell surface protein belonging to the TNF receptor superfamily. It is alternatively known as TNFRSF9, CD137, and ILA. The 255 amino acid human 4-1BB is a type I transmembrane protein having in its extracellular domain four of the cysteine-rich motifs that are characteristic of the TNF receptor superfamily. The 30 KD glycoprotein exists both as a monomer and as a dimer on T cells. The human and mouse proteins share 60% amino acid identity.A DNA sequence encoding the N-terminal fragment (Met 1– Gln 186) of the extracellular domain of human 4-1BB (NP_001552.2) was fused with the C-terminal polyhistidine-tagged Fc region of human IgG1 at the C-terminus. |
Purity : | > 97%, as determined by SDS-PAGE and SEC-HPLC Analysis |
Predicted N terminal : | Gln 25 |
Endotoxin : | < 1.0 EU per 1 μg of the cytokine as determined by the LAL method |
Formulation : | Supplied as a 0.2μm filtered solution of PBS, pH7.4 |
Reconstitution : | Follow the instructions on the vial. Centrifuge the vial at 4°Cbefore opening to recover the entire contents. |
Stability : | Samples are stable for up to twelve months from date of receipt -70C |
Storage : | Store at –70°C; Avoid repeated freeze-thaw cycles |
Gene Name : | TNFRSF9 |
Synonyms : | 4-1BB; CD137; CDw137; ILA; MGC2172; 4-1BB ligand receptor; CD137 antigen; OTTHUMP00000001360; OTTHUMP00000044294; T cell antigen ILA; homolog of mouse 4-1BB; induced by lymphocyte activation (ILA); interleukin-activated receptor, homolog of mouse Ly63; receptor protein 4-1BB; TNFRSF9; tumor necrosis factor receptor superfamily, member 9 |
Gene ID : | 3604 |
mRNA Refseq : | NM_001561 |
Protein Refseq : | NP_001552 |
MIM : | 602250 |
UniProt ID : | Q07011 |
Chromosome Location : | 1p36 |
Pathway : | Cytokine-cytokine receptor interaction |
Function : | induction of apoptosis; negative regulation of cell proliferase |
◆ Recombinant Protein
TNFRSF9-346H | Recombinant Human TNFRSF9 Protein, Fc & Avi-tagged, Biotinylated | +Inquiry |
Tnfrsf9-453M | Recombinant Mouse Tnfrsf9 Protein, His-tagged | +Inquiry |
TNFRSF9-329H | Recombinant Human TNFRSF9 Protein (Met1-Gln186), His-tagged, Biotinylated | +Inquiry |
TNFRSF9-550R | Recombinant Rhesus TNFRSF9 Protein, His-tagged | +Inquiry |
TNFRSF9-328H | Recombinant Human TNFRSF9 Protein (Met1-Gln186), His-Fc-tagged, Biotinylated | +Inquiry |
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◆ Lysates
TNFRSF9-928CCL | Recombinant Canine TNFRSF9 cell lysate | +Inquiry |
TNFRSF9-1792MCL | Recombinant Mouse TNFRSF9 cell lysate | +Inquiry |
TNFRSF9-2162HCL | Recombinant Human TNFRSF9 cell lysate | +Inquiry |
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TNFRSF10A Tnfrsf10b TNFRSF10C TNFRSF10D TNFRSF11A TNFRSF11B Tnfrsf12a TNFRSF13B TNFRSF13C TNFRSF14 Tnfrsf17 Tnfrsf18 Tnfrsf19 TNFRSF1A TNFRSF1B TNFRSF21 Tnfrsf22 Tnfrsf23 TNFRSF25 Tnfrsf26 TNFRSF4 TNFRSF6B TNFRSF8 TNFRSF9 TNFRSF12
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