Recombinant Human TNFRSF9, Fc-tagged TNFRSF9-43H

Recombinant Human TNFRSF9, Fc-tagged


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Cat.No. : TNFRSF9-43H Optional Service: Optional requirements on this protein
Product Overview : Recombinant Human TNFRSF9, Fc-tagged expressed in human cells is a disulfide-linked homodimeric protein. The reduced monomer consists of 409 amino acids and has a calculated molecular mass of 45.2 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rh4-1BB/Fc monomer is approximately 60-65 kDa due to glycosylation
Description : 4-1BB is an inducible T cell surface protein belonging to the TNF receptor superfamily. It is alternatively known as TNFRSF9, CD137, and ILA. The 255 amino acid human 4-1BB is a type I transmembrane protein having in its extracellular domain four of the cysteine-rich motifs that are characteristic of the TNF receptor superfamily. The 30 KD glycoprotein exists both as a monomer and as a dimer on T cells. The human and mouse proteins share 60% amino acid identity.A DNA sequence encoding the N-terminal fragment (Met 1– Gln 186) of the extracellular domain of human 4-1BB (NP_001552.2) was fused with the C-terminal polyhistidine-tagged Fc region of human IgG1 at the C-terminus.
Purity : > 97%, as determined by SDS-PAGE and SEC-HPLC Analysis
Predicted N terminal : Gln 25
Endotoxin : < 1.0 EU per 1 μg of the cytokine as determined by the LAL method
Formulation : Supplied as a 0.2μm filtered solution of PBS, pH7.4
Reconstitution : Follow the instructions on the vial. Centrifuge the vial at 4°Cbefore opening to recover the entire contents.
Stability : Samples are stable for up to twelve months from date of receipt -70C
Storage : Store at –70°C; Avoid repeated freeze-thaw cycles
Gene Name : TNFRSF9
Synonyms : 4-1BB; CD137; CDw137; ILA; MGC2172; 4-1BB ligand receptor; CD137 antigen; OTTHUMP00000001360; OTTHUMP00000044294; T cell antigen ILA; homolog of mouse 4-1BB; induced by lymphocyte activation (ILA); interleukin-activated receptor, homolog of mouse Ly63; receptor protein 4-1BB; TNFRSF9; tumor necrosis factor receptor superfamily, member 9
Gene ID : 3604
mRNA Refseq : NM_001561
Protein Refseq : NP_001552
MIM : 602250
UniProt ID : Q07011
Chromosome Location : 1p36
Pathway : Cytokine-cytokine receptor interaction
Function : induction of apoptosis; negative regulation of cell proliferase
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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