"TNFRSF9" Related Products

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Recombinant Human TNFRSF9, Fc-tagged

Cat. No.: TNFRSF9-43H
Product Overview: Recombinant Human TNFRSF9, Fc-tagged expressed in human cells is a disulfide-linked homodimeric protein. The reduced monomer consists of 409 amino acids and has a calculated molecular mass of 45.2 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rh4-1BB/Fc monomer is approximately 60-65 kDa due to glycosylation
Description: 4-1BB is an inducible T cell surface protein belonging to the TNF receptor superfamily. It is alternatively known as TNFRSF9, CD137, and ILA. The 255 amino acid human 4-1BB is a type I transmembrane protein having in its extracellular domain four of the cysteine-rich motifs that are characteristic of the TNF receptor superfamily. The 30 KD glycoprotein exists both as a monomer and as a dimer on T cells. The human and mouse proteins share 60% amino acid identity.A DNA sequence encoding the N-terminal fragment (Met 1– Gln 186) of the extracellular domain of human 4-1BB (NP_001552.2) was fused with the C-terminal polyhistidine-tagged Fc region of human IgG1 at the C-terminus.
Purity: > 97%, as determined by SDS-PAGE and SEC-HPLC Analysis
Predicted N terminal: Gln 25
Endotoxin: < 1.0 EU per 1 μg of the cytokine as determined by the LAL method
Formulation: Supplied as a 0.2μm filtered solution of PBS, pH7.4
Reconstitution: Follow the instructions on the vial. Centrifuge the vial at 4°Cbefore opening to recover the entire contents.
Stability: Samples are stable for up to twelve months from date of receipt -70C
Storage: Store at –70°C; Avoid repeated freeze-thaw cycles
Gene Name: TNFRSF9
Synonyms: 4-1BB; CD137; CDw137; ILA; MGC2172; 4-1BB ligand receptor; CD137 antigen; OTTHUMP00000001360; OTTHUMP00000044294; T cell antigen ILA; homolog of mouse 4-1BB; induced by lymphocyte activation (ILA); interleukin-activated receptor, homolog of mouse Ly63; receptor protein 4-1BB; TNFRSF9; tumor necrosis factor receptor superfamily, member 9
Gene ID: 3604
mRNA Refseq: NM_001561
Protein Refseq: NP_001552
MIM: 602250
UniProt ID: Q07011
Chromosome Location: 1p36
Pathway: Cytokine-cytokine receptor interaction
Function: induction of apoptosis; negative regulation of cell proliferase

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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