| Cat.No. : |
TNFRSF9-43H
Optional Service: Optional requirements on this protein
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| Product Overview : |
Recombinant Human TNFRSF9, Fc-tagged expressed in human cells is a disulfide-linked homodimeric protein. The reduced monomer consists of 409 amino acids and has a calculated molecular mass of 45.2 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rh4-1BB/Fc monomer is approximately 60-65 kDa due to glycosylation |
| Description : |
4-1BB is an inducible T cell surface protein belonging to the TNF receptor superfamily. It is alternatively known as TNFRSF9, CD137, and ILA. The 255 amino acid human 4-1BB is a type I transmembrane protein having in its extracellular domain four of the cysteine-rich motifs that are characteristic of the TNF receptor superfamily. The 30 KD glycoprotein exists both as a monomer and as a dimer on T cells. The human and mouse proteins share 60% amino acid identity.A DNA sequence encoding the N-terminal fragment (Met 1– Gln 186) of the extracellular domain of human 4-1BB (NP_001552.2) was fused with the C-terminal polyhistidine-tagged Fc region of human IgG1 at the C-terminus. |
| Purity : |
> 97%, as determined by SDS-PAGE and SEC-HPLC Analysis |
| Predicted N terminal : |
Gln 25 |
| Endotoxin : |
< 1.0 EU per 1 μg of the cytokine as determined by the LAL method |
| Formulation : |
Supplied as a 0.2μm filtered solution of PBS, pH7.4 |
| Reconstitution : |
Follow the instructions on the vial. Centrifuge the vial at 4°Cbefore opening to recover the entire contents. |
| Stability : |
Samples are stable for up to twelve months from date of receipt -70C |
| Storage : |
Store at –70°C; Avoid repeated freeze-thaw cycles |
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.