Recombinant Human HLA-DRB1, His-tagged
Cat.No. : | HLA-DRB1-5089H |
Product Overview : | Recombinant human HLA-DRB1 protein, fused to His-tag at N-terminus, was expressed in E.coli. |
- Specification
- Gene Information
- Related Products
Description : | HLA-DRB1 belongs to the HLA class II beta chain paralogs. The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa. It is encoded by 6 exons. Exon one encodes the leader peptide; exons 2 and 3 encode the two extracellular domains; exon 4 encodes the transmembrane domain; and exon 5 encodes the cytoplasmic tail. |
Source : | E. coli |
Species : | Human |
Tag : | His |
Form : | Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.4M Urea, 10% glycerol |
Molecular Mass : | 25.2 kDa (219aa) |
AA Sequence : | MGSSHHHHHH SSGLVPRGSH MGDTRPRFLW QPKRECHFFN GTERVRFLDR YFYNQEESVR FDSDVGEFRA VTELGRPDAE YWNSQKDILE QARAAVDTYC RHNYGVVESF TVQRRVQPKV TVYPSKTQPL QHHNLLVCSV SGFYPGSIEV RWFLNGQEEK AGMVSTGLIQ NGDWTFQTLV MLETVPRSGE VYTCQVEHPS VTSPLTVEWR ARSESAQSK |
Purity : | >85% by SDS - PAGE |
Applications : | SDS-PAGE |
Storage : | Can be stored at +4centigrade short term (1-2 weeks). For long term storage, aliquot and store at -20centigrade or -70centigrade. Avoid repeated freezing and thawing cycles. |
Concentration : | 1 mg/ml (determined by Bradford assay) |
Gene Name : | HLA-DRB1 major histocompatibility complex, class II, DR beta 1 [ Homo sapiens ] |
Official Symbol : | HLA-DRB1 |
Synonyms : | HLA-DRB1; major histocompatibility complex, class II, DR beta 1; HLA DR1B; DW2.2/DR2.2; MHC class II antigen; lymphocyte antigen DRB1; MHC class II HLA-DRw10-beta; human leucocyte antigen DRB1; MHC class II HLA-DR beta 1 chain; MHC class II HLA-DR-beta cell surface glycoprotein; HLA class II histocompatibility antigen, DR-1 beta chain; SS1; DRB1; DRw10; HLA-DRB; HLA-DR1B; FLJ75017; FLJ76359; |
Gene ID : | 3123 |
mRNA Refseq : | NM_001243965 |
Protein Refseq : | NP_001230894 |
MIM : | 142857 |
UniProt ID : | P01911 |
Chromosome Location : | 6p21.3 |
Pathway : | Adaptive Immune System, organism-specific biosystem; Allograft rejection, organism-specific biosystem; Allograft rejection, conserved biosystem; Antigen processing and presentation, organism-specific biosystem; Antigen processing and presentation, conserved biosystem; Asthma, organism-specific biosystem; Asthma, conserved biosystem; |
Function : | MHC class II receptor activity; MHC class II receptor activity; |
Products Types
◆ Recombinant Protein | ||
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HLA-DRB1-357H | Recombinant Human HLA-DRB1 Protein, His-tagged | +Inquiry |
HLA-DRB1-1240H | Recombinant Human HLA-DRB1 Protein, His-SUMO/MYC-tagged | +Inquiry |
HLA-DRB1-01H | Recombinant Human HLA-DRB1 protein, His-tagged | +Inquiry |
HLA-DRB1-488H | Recombinant Human major histocompatibility complex, class II, DR beta 1, His-tagged | +Inquiry |
◆ Lysates | ||
HLA-DRB1-797HCL | Recombinant Human HLA-DRB1 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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