Active Recombinant Human PDCD1, Fc-tagged

• Cat.No.: PDCD1-189H
• Product Overview: The extracellular domain of human CD279 [PD-1] (aa 25-167) is fused to the N-terminus of the Fc region of a mutant human IgG1.

Specification

• Description: This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases.
• Source: CHO cells
• Species: Human
• Tag: Fc
• Form: Lyophilized from 0.2μm-filtered solution in PBS.
• Bio-activity: Shows the biological function of the CD279 moiety and exerts a prolonged circulating half-life caused by the modified Fc domain.
• Endotoxin: <0.06EU/μg protein.
• Purity: ≥98% (SDS-PAGE)
• Storage: Avoid freeze/thaw cycles. Short Term Storage: +4°C Long Term Storage: -20°C
• Reconstitution: Reconstitute at 100μg/ml in sterile PBS.

Gene Information

• Gene Name: PDCD1 programmed cell death 1 [ Homo sapiens (human) ]
• Official Symbol: PDCD1
• Synonyms: PDCD1; PD1; PD-1; CD279; SLEB2; hPD-1; hPD-l; programmed cell death 1; programmed cell death protein 1; protein PD-1
• Gene ID: 5133
• mRNA Refseq: NM_005018
• Protein Refseq: NP_005009
• MIM: 600244
• UniProt ID: Q15116
• Chromosome Location: 2q37.3
• Pathway: Adaptive Immune System; Cell adhesion molecules (CAMs); Immune System
• Function: protein binding; signal transducer activity