"PAX8" Related Products

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Recombinant Human paired box 8, His-tagged

Cat.No.: PAX8-675H
Product Overview: PAX8, 1-287aa Human, His tag, E.coli
Description: Paired box protein Pax-8 isoform PAX8E, also known as PAX8, is expressed in the developing and adult thyroid, the developing secretory system and at lower levels, in the adult kidney. PAX8complexes with TTF-1 and TTF-2 to induce thyroid follicular cell differentiation and thyroid hormone biosynthesis by regulating the expression of sodium iodide symporter (NIS), thyroid peroxidase (TPO), thyroglobulin (TG) and the thyrotropin receptor (TSHR). Defects in PAX8 are the cause of congenital hypothyroidism non-goitrous type 2 (CHNG2). Recombinant human PAX8 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
Source: E.coli
Species: Human
Tag: His-tag
Form: Liquid. In Phosphate buffer saline (pH 7.4) containing 20% glycerol, 1mM DTT
Molecular Mass: 33.4 kDa (310aa) confirmed by MALDI-TOF
AA Sequence: MGSSHHHHHH SSGLVPRGSH MGSMPHNSIR SGHGGLNQLG GAFVNGRPLP EVVRQRIVDL AHQGVRPCDI SRQLRVSHGC VSKILGRYYE TGSIRPGVIG GSKPKVATPK VVEKIGDYKR QNPTMFAWEI RDRLLAEGVC DNDTVPSVSS INRIIRTKVQ QPFNLPMDSC VATKSLSPGH TLIPSSAVTP PESPQSDSLG STYSINGLLG IAQPGSDKRK MDDSDQDSCR LSIDSQSSSS GPRKHLRTDA FSQHHLEPLE CPFERQHYPE AYASPSHTKG EQEVNTLAMP MATPPTPPTA RPGASPTPAC
Purity: >90% by SDS - PAGE
Storage: Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
Concentration: 0.25 mg/ml (determined by Bradford assay)
Gene Name: PAX8 paired box 8 [ Homo sapiens ]
Official Symbol: PAX8
Synonyms: PAX8; paired box 8; paired box gene 8; paired box protein Pax-8; paired domain gene 8;
Gene ID: 7849
mRNA Refseq: NM_003466
Protein Refseq: NP_003457
MIM: 167415
UniProt ID: Q06710
Chromosome Location: 2q13
Pathway: Id Signaling Pathway, organism-specific biosystem; Pathways in cancer, organism-specific biosystem; Thyroid cancer, organism-specific biosystem; Thyroid cancer, conserved biosystem; Transcriptional misregulation in cancer, organism-specific biosystem; Transcriptional misregulation in cancer, conserved biosystem;
Function: DNA binding; DNA binding; RNA polymerase II core promoter sequence-specific DNA binding; protein binding; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; thyroid-stimulating hormone receptor activity; transcript

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