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Recombinant Human Resistin

Cat.No. : RETN-70H
Product Overview : Recombinant Human Resistin is a 9.9 kDa protein containing 93 amino acid residues. It was expressed in E.coli. ASSKTLCSME EAINERIQEV AGSLIFRAIS SIGLECQSVT SRGDLATCPR GFAVTGCTCG SACGSWDVRA ETTCHCQCAG MDWTGARCCR VQP.
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Cat. No. : RETN-70H
Description : Resistin, a product of the RSTN gene, is a peptide hormone belonging to the class of cysteine-rich secreted proteins which is termed the RELM family, and is also described as ADSF (Adipose Tissue- Specific Secretory Factor) and FIZZ3 (Found in Inflammatory Zone). Human resistin contains 108 amino acids as a prepeptide, and its hydrofobic signal peptide is cleaved before its secretion. Resistin circulates in human blood as a dimeric protein consisting of two 92 amino acid polypeptides, which are disulfide-linked via Cys26. Resistin may be an important link between obesity and insulin resistance.
Source : Escherichia Coli.
Specificity : The amino acid sequence of the Resistin Human Recombinant is homologous to the amino acid sequence of the Resistin Human without signal sequence.
Purification Method : Two-step procedure using size exclusion chromatography before and after refolding.
Purity : >98% (SDS-PAGE analyzed).
Formulation : Recombinant Human Resistin was lyophilized from a concentrated (1 mg/ml) solution containg 0.03% NaHCO3.
Solubility : Add 0.2 ml of deionized water and let the lyophilized pellet dissolve completely.
Specific Activity : The biological activity was evidenced by the Resistin ability to prevent insulin-stimulated uptake of deoxy glucose in several cell lines at 10 ng/ml concentration.
Stability : Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C. The lyophilized protein remains stable until the expiry date when stored at -20°C.
Gene Name : RETN resistin [ Homo sapiens ]
Synonyms : RETN; resistin; ADSF; RSTN; XCP1; MGC126603; MGC126609; found in inflammatory zone 3;C/EBP-epsilon regulated myeloid-specific secreted cysteine-rich protein precursor 1; HXCP1; Adipose tissue-specific secretory factor; FIZZ3; RETN1; C/EBP-epsilon-regulated myeloid-specific secretedcysteine-rich protein; Cysteine-rich secreted protein A12-alpha-like 2; Cysteine-rich secreted protein FIZZ3
Gene ID : 56729
mRNA Refseq : NM_020415
Protein Refseq : NP_065148
MIM : 605565
UniProt ID : Q9HD89
Chromosome Location : 19p13.2
Function : hormone activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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How does the expression level of RETN correlate with insulin resistance? 11/03/2022

Expression level of RETN is associated with the development of insulin resistance. High levels of RETN can reduce insulin sensitivity, leading to decreased glycemic control, which promotes the development of insulin resistance.

What is the role of RETN in the treatment of diabetes and cardiovascular disease? 08/13/2022

Studies have shown that regulating the expression level of RETN can influence the development and treatment effect of diabetes and cardiovascular disease. For example, certain drugs can improve insulin sensitivity and control blood sugar levels by inhibiting the expression level of RETN.

How can the expression level of RETN be used for the prediction and diagnosis of diabetes and cardiovascular disease? 05/11/2022

Diabetes and cardiovascular disease can be predicted and diagnosed by measuring the expression level of RETN. For example, high levels of RETN may indicate a higher risk of disease and more severe disease conditions.

How to use mutation or abnormal expression of RETN for disease diagnosis and prognosis assessment? 12/21/2021

Mutations and expression levels of the RETN gene can be detected to aid in diagnosing disease and assessing prognosis. For example, certain mutations may predict a higher risk and a worse prognosis.

What diseases are mutations or abnormal expression of RETN associated with? 04/22/2020

Mutations or abnormal expression of RETN may be associated with a variety of diseases. For example, certain mutations can lead to abnormally elevated levels of their expression, increasing the risk of diabetes, cardiovascular disease, etc.

How does RETN relate to other biomarkers? 05/16/2019

RETN has some association with other biomarkers. For example, in obesity and cardiovascular disease, the expression level of RETN can be used to assess the prognosis and therapeutic effect of the disease together with biomarkers such as adiponectin and leptin.

Customer Reviews (3)

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Reviews
06/22/2020

    Catalytic activity of RETN is excellent, no matter what the environment can maintain stable catalytic performance, its reliability is reliable.

    05/27/2020

      The quality of RETN they produce is guaranteed, and we can buy it with confidence.

      05/22/2019

        The stability of RETN is too strong to ignore, and it remains admirably stable after long storage.

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