Recombinant Human HGF, His-tagged HGF-593H

Recombinant Human HGF, His-tagged


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Recombinant Human HGF, His-tagged

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Cat.No. : HGF-593H
Product Overview : Recombinant Human HGF Protein(Met1-Ser728), made in HEK293, with C-His Tag.
Description : Hepatocyte growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor. Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration. It is secreted as a single inactive polypeptide and is cleaved by serine proteases into a 69-kDa alpha-chain and 34-kDa beta-chain. A disulfide bond between the alpha and beta chains produces the active, heterodimeric molecule. The protein belongs to the plasminogen subfamily of S1 peptidases but has no detectable protease activity. Alternative splicing of this gene produces multiple transcript variants encoding different isoforms.
Source : HEK293
Species : Human
Tag : His
Form : Protein in PBS (with 5% trehalose and mannitol) was 0.22 µm filtered before lyophilized.
Endotoxin : Less than 1.0 EU/µg by LAL method
Purity : > 95% as determined by SDS-PAGE
Storage : Lyophilized form is stable at room temperature for 3 weeks. Keep desiccated at below -18°C for long term storage. After reconstituted, store at 4°C for 2-7 days or at below -18°C for up to 3 months.
Reconstitution : Reconstitute lyophilized powder with water to no less than 100 µg/ml, which can be further diluted in other desired aqueous solutions.
Gene Name : HGF hepatocyte growth factor (hepapoietin A; scatter factor) [ Homo sapiens (human) ]
Official Symbol : HGF
Synonyms : HGF; SF; HGFB; HPTA; F-TCF; DFNB39; hepatocyte growth factor (hepapoietin A; scatter factor); hepatocyte growth factor; hepatopoeitin-A; hepatopoietin-A; lung fibroblast-derived mitogen; fibroblast-derived tumor cytotoxic factor
Gene ID : 3082
mRNA Refseq : NM_000601
Protein Refseq : NP_000592
MIM : 142409
UniProt ID : P14210
Chromosome Location : 7q21.1
Pathway : Arf6 signaling events; Cytokine Signaling in Immune system; Cytokine-cytokine receptor interaction
Function : chemoattractant activity; growth factor activity; identical protein binding

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