Recombinant Human FOXO3, MYC/DDK-tagged

• Cat.No.: FOXO3-2811H
• Product Overview: Recombinant Human FOXO3, fused with C-terminal MYC/DDK, was expressed in HEK293 cells.

Specification

• Description: This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same protein have been observed.
• Source: HEK293 cells
• Species: Human
• Tag: MYC/DDK
• Molecular Mass: 71.1 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: FOXO3 forkhead box O3 [ Homo sapiens ]
• Official Symbol: FOXO3
• Synonyms: FOXO3; forkhead box O3; FOXO2; AF6q21; FKHRL1; FOXO3A; FKHRL1P2; forkhead box protein O3; forkhead box O3A; forkhead in rhabdomyosarcoma-like 1; forkhead homolog (rhabdomyosarcoma) like 1; forkhead, Drosophila, homolog of, in rhabdomyosarcoma-like 1
• Gene ID: 2309
• mRNA Refseq: NM_201559
• Protein Refseq: NP_963853
• MIM: 602681
• UniProt ID: O43524
• Chromosome Location: 6q21
• Pathway: AKT phosphorylates targets in the nucleus; Adaptive Immune System; Chemokine signaling pathway
• Function: DNA binding; DNA binding, bending; protein kinase binding