Recombinant Human FLT1, His-tagged FLT1-32H

Recombinant Human FLT1, His-tagged

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Cat.No. : FLT1-32H Optional Service: Optional requirements on this protein
Product Overview : A DNA sequence encoding the human FLT1 (Met1-Ile328) was expressed with a polyhistidine tag at the C-terminus.
Description : This gene encodes a member of the vascular endothelial growth factor receptor (VEGFR) family. VEGFR family members are receptor tyrosine kinases (RTKs) which contain an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and a tyrosine kinase (TK) domain within the cytoplasmic domain. This protein binds to VEGFR-A, VEGFR-B and placental growth factor and plays an important role in angiogenesis and vasculogenesis. Expression of this receptor is found in vascular endothelial cells, placental trophoblast cells and peripheral blood monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Isoforms include a full-length transmembrane receptor isoform and shortened, soluble isoforms. The soluble isoforms are associated with the onset of pre-eclampsia.
Source : Human Cells
Species : Human
Tag : His
Predicted N Terminal : Ser 27
Form : Lyophilized from sterile PBS, pH 7.4.
Molecular Mass : The recombinant human FLT1 consists 313 amino acids and predicts a molecular mass of 35.6 kDa.
Endotoxin : <1.0 EU per μg protein as determined by the LAL method.
Purity : > 95 % as determined by SDS-PAGE.
Storage : Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Gene Name : FLT1 fms-related tyrosine kinase 1 [ Homo sapiens (human) ]
Official Symbol : FLT1
Synonyms : FLT1; fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor); FLT; VEGFR1; vascular endothelial growth factor receptor 1; EC 2.7.10.1; VEGFR-1; Vascular permeability factor receptor; Flt-1; Tyrosine-protein kinase receptor FLT; Tyrosine-protein kinase FRT; Fms-like tyrosine kinase 1; FRT
Gene ID : 2321
mRNA Refseq : NM_002019
Protein Refseq : NP_002010
MIM : 165070
UniProt ID : P17948
Chromosome Location : 13q12
Pathway : Cytokine-cytokine receptor interaction; HIF-1 signaling pathway; Id Signaling Pathway
Function : ATP binding; VEGF-A-activated receptor activity; growth factor binding
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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