Recombinant Mouse Flt1 protein, His-tagged
Cat.No. : | Flt1-1838M |
Product Overview : | Recombinant Mouse Flt1 aa. (Ser27~Val329) fused with N-terminal His tag was produced in E. coli cells. |
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Source : | E. coli |
Species : | Mouse |
Tag : | His |
Form : | Freeze-dried powder |
Molecular Mass : | 37kDa as determined by SDS-PAGE reducing conditions. |
Protein length : | Ser27~Val329 |
Endotoxin : | <1.0EU per 1ug (determined by the LAL method) |
Purity : | >98% |
Characteristic : | The isoelectric point is 9.7. |
Applications : | SDS-PAGE; WB; ELISA; IP; CoIP; Reporter Assays; Purification; Amine Reactive Labeling. |
Stability : | The thermal stability is described by the loss rate of the target protein. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. (Referring from China Biological Products Standard, which was calculated by the Arrhenius equation.) The loss of this protein is less than 5% within the expiration date under appropriate storage condition. |
Storage : | Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months. |
Concentration : | 200μg/mL |
Storage Buffer : | PBS, pH7.4, containing 1mM DTT, 5% trehalose, 0.01% sarcosyl and Proclin300. |
Reconstitution : | Reconstitute in PBS (pH7.4) to a concentration of 0.1-1.0 mg/mL. Do not vortex. |
Gene Name : | Flt1 FMS-like tyrosine kinase 1 [ Mus musculus (house mouse) ] |
Official Symbol : | Flt1 |
Synonyms : | Lipa; lipase A, lysosomal acid type; LAL; Lip1; Chole; Chole2; lysosomal acid lipase/cholesteryl ester hydrolase; Cholesterol esterase (pancreatic) see D3Wox12 D3Wox13 D3Wox26 and D3Mgh25; acid cholesteryl ester hydrolase; cholesteryl esterase; lipase A, lysosomal acid, cholesterol esterase; lysosomal acid lipase 1; lysosomal acid lipase A; pancreatic cholesterol esterase; sterol esterase |
Gene ID : | 14254 |
mRNA Refseq : | NM_010228.3 |
Protein Refseq : | NP_034358.2 |
UniProt ID : | P35969 |
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◆ Lysates | ||
FLT1-1207RCL | Recombinant Rat FLT1 cell lysate | +Inquiry |
FLT1-1909HCL | Recombinant Human FLT1 cell lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Customer Reviews (3)
Write a reviewthe FLT1 protein is an excellent choice for researchers due to its high quality, reliability, and the comprehensive technical support provided by the manufacturer.
The manufacturer of FLT1 protein provides excellent technical support, ensuring that researchers receive prompt assistance and guidance when encountering any challenges or difficulties.
Researchers can confidently incorporate FLT1 protein into their experiments, knowing that they have access to a reliable resource that will meet their experimental needs effectively.
Q&As (5)
Ask a questionElevated levels of soluble FLT1 have been associated with preeclampsia, a pregnancy complication. Soluble FLT1 acts as a decoy receptor, reducing the bioavailability of VEGF and contributing to vascular dysfunction.
FLT1 has been implicated in retinal diseases like diabetic retinopathy, where abnormal blood vessel growth can lead to vision impairment. Inhibiting FLT1 may help regulate angiogenesis in such conditions.
FLT1 expression is regulated by various factors, including VEGF itself, as well as hypoxia and inflammation. These factors influence the balance of angiogenic signaling.
Yes, elevated levels of soluble FLT1 have been investigated as potential biomarkers for conditions like preeclampsia, cancer, and certain cardiovascular diseases.
Yes, targeting FLT1 is a strategy for anti-angiogenic therapy. Inhibiting FLT1 can impede blood vessel formation, limiting the blood supply to tumors and potentially slowing their growth.
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