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Recombinant Human ROCK2 protein, MYC/DDK-tagged

Cat.No. : ROCK2-672H
Product Overview : Recombinant Human ROCK2 fused with MYC/DDK tag at C-terminal was expressed in HEK293.
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  • Gene Information
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Description : The protein encoded by this gene is a serine/threonine kinase that regulates cytokinesis, smooth muscle contraction, the formation of actin stress fibers and focal adhesions, and the activation of the c-fos serum response element. This protein, which is an isozyme of ROCK1 is a target for the small GTPase Rho.
Source : HEK293
Species : Human
Tag : MYC/DDK
Form : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Mass : 160.7 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration : >50 ug/mL as determined by microplate BCA method
Gene Name : ROCK2 Rho-associated, coiled-coil containing protein kinase 2 [ Homo sapiens ]
Official Symbol : ROCK2
Synonyms : ROCK2; Rho-associated, coiled-coil containing protein kinase 2; rho-associated protein kinase 2; p164 ROCK-2; rho-associated, coiled-coil-containing protein kinase II; ROCK-II; KIAA0619;
Gene ID : 9475
mRNA Refseq : NM_004850
Protein Refseq : NP_004841
MIM : 604002
UniProt ID : O75116
Chromosome Location : 2p24
Pathway : Axon guidance, organism-specific biosystem; Axon guidance, conserved biosystem; Axon guidance, organism-specific biosystem; Chemokine signaling pathway, organism-specific biosystem; Chemokine signaling pathway, conserved biosystem; Developmental Biology, organism-specific biosystem; Focal Adhesion, organism-specific biosystem;
Function : ATP binding; metal ion binding; nucleotide binding; protein binding; protein serine/threonine kinase activity; structural molecule activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Discuss the role of ROCK2 in smooth muscle contraction and vascular tone. 03/24/2022

ROCK2 is a key regulator of smooth muscle contraction, influencing vascular tone by phosphorylating myosin light chain and promoting actin-myosin interaction.

Describe the molecular crosstalk between ROCK2 and other signaling pathways. 08/07/2021

ROCK2 interacts with various signaling pathways, including Wnt, PI3K/Akt, and MAPK pathways, forming a network that regulates cell survival, proliferation, and differentiation.

How does ROCK2 contribute to the regulation of cell cycle progression? 12/04/2020

ROCK2 can influence the cell cycle by regulating cyclin-dependent kinase activity and promoting the phosphorylation of proteins involved in cell cycle checkpoints.

What are the implications of ROCK2 in cell migration and invasion? 03/18/2019

ROCK2 is involved in the regulation of cell migration and invasion by controlling actin dynamics and focal adhesion turnover, influencing processes like metastasis in cancer.

Discuss the role of ROCK2 in the regulation of the actin cytoskeleton. 06/11/2018

ROCK2 phosphorylates various downstream targets, such as myosin light chain, leading to actin-myosin contraction and the reorganization of the actin cytoskeleton.

Customer Reviews (3)

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Reviews
08/19/2021

    Swift and hassle-free delivery ensured our experiments stayed on track.

    01/13/2020

      Efficient customer service provided valuable insights for our decision-making.

      07/06/2019

        Reliable and precise—this recombined protein never disappoints.

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