Recombinant Human ROCK2 protein, MYC/DDK-tagged
Cat.No. : | ROCK2-672H |
Product Overview : | Recombinant Human ROCK2 fused with MYC/DDK tag at C-terminal was expressed in HEK293. |
- Specification
- Gene Information
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Description : | The protein encoded by this gene is a serine/threonine kinase that regulates cytokinesis, smooth muscle contraction, the formation of actin stress fibers and focal adhesions, and the activation of the c-fos serum response element. This protein, which is an isozyme of ROCK1 is a target for the small GTPase Rho. |
Source : | HEK293 |
Species : | Human |
Tag : | MYC/DDK |
Form : | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Molecular Mass : | 160.7 kDa |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Concentration : | >50 ug/mL as determined by microplate BCA method |
Gene Name : | ROCK2 Rho-associated, coiled-coil containing protein kinase 2 [ Homo sapiens ] |
Official Symbol : | ROCK2 |
Synonyms : | ROCK2; Rho-associated, coiled-coil containing protein kinase 2; rho-associated protein kinase 2; p164 ROCK-2; rho-associated, coiled-coil-containing protein kinase II; ROCK-II; KIAA0619; |
Gene ID : | 9475 |
mRNA Refseq : | NM_004850 |
Protein Refseq : | NP_004841 |
MIM : | 604002 |
UniProt ID : | O75116 |
Chromosome Location : | 2p24 |
Pathway : | Axon guidance, organism-specific biosystem; Axon guidance, conserved biosystem; Axon guidance, organism-specific biosystem; Chemokine signaling pathway, organism-specific biosystem; Chemokine signaling pathway, conserved biosystem; Developmental Biology, organism-specific biosystem; Focal Adhesion, organism-specific biosystem; |
Function : | ATP binding; metal ion binding; nucleotide binding; protein binding; protein serine/threonine kinase activity; structural molecule activity; |
Products Types
◆ Recombinant Protein | ||
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ROCK2-37M | Recombinant Active Mouse ROCK2 Protein (5-554), N-His-tagged | +Inquiry |
Rock2-5568M | Recombinant Mouse Rock2 Protein, Myc/DDK-tagged | +Inquiry |
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ROCK2-1879H | Active Recombinant Human ROCK2 Protein, His-tagged | +Inquiry |
◆ Lysates | ||
ROCK2-2255HCL | Recombinant Human ROCK2 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionROCK2 is a key regulator of smooth muscle contraction, influencing vascular tone by phosphorylating myosin light chain and promoting actin-myosin interaction.
ROCK2 interacts with various signaling pathways, including Wnt, PI3K/Akt, and MAPK pathways, forming a network that regulates cell survival, proliferation, and differentiation.
ROCK2 can influence the cell cycle by regulating cyclin-dependent kinase activity and promoting the phosphorylation of proteins involved in cell cycle checkpoints.
ROCK2 is involved in the regulation of cell migration and invasion by controlling actin dynamics and focal adhesion turnover, influencing processes like metastasis in cancer.
ROCK2 phosphorylates various downstream targets, such as myosin light chain, leading to actin-myosin contraction and the reorganization of the actin cytoskeleton.
Customer Reviews (3)
Write a reviewSwift and hassle-free delivery ensured our experiments stayed on track.
Efficient customer service provided valuable insights for our decision-making.
Reliable and precise—this recombined protein never disappoints.
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