||Recombinant Human Cyclophilin-B produced inE.Coliis a single, non-glycosylated, polypeptide chain containing 192 amino acids (26-216) and having a molecular mass of 21.2 kDa. CAMLG is purified by proprietary chromatographic techniques.
||Cyclophilin B (also known as PPIB, peptidylpropyl isomerase B) is a cyclosporine-binding protein and is mainly located within the endoplasmic reticulum. It is associated with the secretory pathway and released in biological fluids. This protein can bind to cells derived from T- and B-lymphocytes, and may regulate cyclosporine A-mediated immunosuppression.
|Amino Acid Sequence:
||MLLPGPSAAD EKKKGPKVTV KVYFDLRIGD EDVGRVIFGL FGKTVPKTVD NFVALATGEKGFGYKNSKFH RVIKDFMIQG GDFTRGDGTG GKSIYGERFP DENFKLKHYG PGWVSMANAGKDTNGSQFFI TTVKTAWLDG KHVVFGKVLE GMEVVRKVES TKTDSRDKPL KDVIIADCGK IEVEKPFAIA KE.
||Sterile filtered colorless solution.
||Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
||1 mg/ml solution containing 20 mM Tris 8.0, 20 mM NaCl, 0.5 mM DTT and 10% glycerol.
||Recombinant Human PPIase although stable at 14°C for 1 week, should be stored desiccated below -18°C. Please prevent freeze thaw cycles.