Recombinant Human Calcium Modulating Ligand

• Cat.No.: CAMLG-63H
• Product Overview: Recombinant Human Cyclophilin-B produced inE.Coliis a single, non-glycosylated, polypeptide chain containing 192 amino acids (26-216) and having a molecular mass of 21.2 kDa. CAMLG is purified by proprietary chromatographic techniques.

Specification

• Cat. No.: CAMLG-63H
• Description: Cyclophilin B (also known as PPIB, peptidylpropyl isomerase B) is a cyclosporine-binding protein and is mainly located within the endoplasmic reticulum. It is associated with the secretory pathway and released in biological fluids. This protein can bind to cells derived from T- and B-lymphocytes, and may regulate cyclosporine A-mediated immunosuppression.
• Source: Escherichia Coli.
• Amino Acid Sequence: MLLPGPSAAD EKKKGPKVTV KVYFDLRIGD EDVGRVIFGL FGKTVPKTVD NFVALATGEKGFGYKNSKFH RVIKDFMIQG GDFTRGDGTG GKSIYGERFP DENFKLKHYG PGWVSMANAGKDTNGSQFFI TTVKTAWLDG KHVVFGKVLE GMEVVRKVES TKTDSRDKPL KDVIIADCGK IEVEKPFAIA KE.
• Physical Appearance: Sterile filtered colorless solution.
• Purity: Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
• Formulation: 1 mg/ml solution containing 20 mM Tris 8.0, 20 mM NaCl, 0.5 mM DTT and 10% glycerol.
• Stability: Recombinant Human PPIase although stable at 14°C for 1 week, should be stored desiccated below -18°C. Please prevent freeze thaw cycles.

Gene Information

• Gene Name: CAMLG calcium modulating ligand [ Homo sapiens ]
• Synonyms: CAMLG; calcium modulating ligand; CAML; calcium-modulating cyclophilin ligand; calcium-signal modulating cyclophilin ligand; cyclophilin B-binding protein;Calcium signal-modulating cyclophilin ligand; MGC163197
• Gene ID: 819
• mRNA Refseq: NM_001745
• Protein Refseq: NP_001736
• MIM: 601118
• UniProt ID: P49069
• Chromosome Location: 5q23
• Function: protein binding