Recombinant Human CAMLG Protein, GST-Tagged

• Cat.No.: CAMLG-0344H
• Product Overview: Human CAMLG full-length ORF (NP_001736.1, 1 a.a. - 296 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: The immunosuppressant drug cyclosporin A blocks a calcium-dependent signal from the T-cell receptor (TCR) that normally leads to T-cell activation. When bound to cyclophilin B, cyclosporin A binds and inactivates the key signaling intermediate calcineurin. The protein encoded by this gene functions similarly to cyclosporin A, binding to cyclophilin B and acting downstream of the TCR and upstream of calcineurin by causing an influx of calcium. This integral membrane protein appears to be a new participant in the calcium signal transduction pathway, implicating cyclophilin B in calcium signaling, even in the absence of cyclosporin. [provided by RefSeq, Jul 2008]
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 59.4 kDa
• AA Sequence: MESMAVATDGGERPGVPAGSGLSAS QRRAELRRRKLLMNSEQRINRIMGF HRPGSGAEEESQTKSKQQDSDKLNS LSVPSVSKRVVLGDSVSTGTTDQQG GVAEVKGTQLGDKLDSFIKPPECSS DVNLELRQRNRGDLTADSVQRGSRH GLEQYLSRFEEAMKLRKQLISEKPS QEDGNTTEEFDSFRIFRLVGCALLA LGVRAFVCKYLSIFAPFLTLQLAYM GLYKYFPKSEKKIKTTVLTAALLLS GIPAEVINRSMDTYSKMGEVFTDLC VYFFTFIFCHELLDYWGSEVP
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: CAMLG calcium modulating ligand [ Homo sapiens ]
• Official Symbol: CAMLG
• Synonyms: CAMLG; calcium modulating ligand; calcium signal-modulating cyclophilin ligand; calcium modulating cyclophilin ligand; calcium signal modulating cyclophilin ligand; CAML; cyclophilin B binding protein; cyclophilin B-binding protein; calcium-modulating cyclophilin ligand; calcium-signal modulating cyclophilin ligand; MGC163197
• Gene ID: 819
• mRNA Refseq: NM_001745
• Protein Refseq: NP_001736
• MIM: 601118
• UniProt ID: P49069