| Cat. No.: | Sco2-170H |
| Product Overview: | RecombinantHuman Sco2 was cloned from Human cDNA and expressed inE.coli. The protein consists of the soluble domain (aa 100-266) of the apo-HSco2SH, which lacks the transmembrane segment (NCBI accession NP_005129). Four additional aa (GSFT) are present at the N-term end of the protein. MW = 19.5 kDa. |
| Description: | Protein SCO2 homolog, mitochondrial is a protein that in humans is encoded by the SCO2 gene. Mammalian cytochrome c oxidase (COX) catalyzes the transfer of reducing equivalents from cytochrome c to molecular oxygen and pumps protons across the inner mitochondrial membrane. In yeast, 2 related COX assembly genes, SCO1 and SCO2 (synthesis of cytochrome c oxidase), enable subunits 1 and 2 to be incorporated into the holoprotein. This gene is the human homolog of the yeast SCO2 gene. |
| Source: | E. Coli. |
| Purity: | >95% by SDS-PAGE. The protein was observed as a single band migrating at a molecular weight of >18kDa. |
| Supplied As: | 1.0mg at 1.0mg/ml in 50Mm KH2PO4/K2HPO4, pH7.2, 1mM Dithiothreitol. The concentration is calculated from the absorbance at 280nm (e280nm =19035M-1cm-1). |
| Characteristics: | Under the above described conditions, to avoid precipitation or protein dimerization, the product can be concentrated to a maximum of 0,7mM under Inert atmosphere. |
| Storage: | -20°C. The protein is stable at 4°C for at least 2 weeks and at 25°C for at least several hours. After initial defrost, aliquot protein into individual tubes and refreeze at –20°C. Avoid repeated freeze/defrost cycles. |
| Gene Name: | SCO2 SCO cytochrome oxidase deficient homolog 2 (yeast) [ Homo sapiens ] |
| Synonyms: | SCO2; SCO cytochrome oxidase deficient homolog 2 (yeast); SCO1L; MGC125823; MGC125825; SCO2; SCO (cytochrome oxidase deficient, yeast) homolog 2;Protein SCO2 homolog, mitochondrial |
| Gene ID: | 9997 |
| mRNA Refseq: | NM_005138 |
| Protein Refseq: | NP_005129 |
| MIM: | 604272 |
| UniProt ID: | O43819 |
| Chromosome Location: | 22q13.33 |
| Function: | copper ion binding;metal ion binding |
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