Recombinant Murine Cardiotrophin 1

• Cat.No.: Ctf1-183M
• Product Overview: Recombinant Murine Cardiotrophin 1 produced inE.coliwas a 21.3kDa protein consisting of 202 amino acid residues.

Specification

• Cat. No.: Ctf1-183M
• Description: CT-1 is a member of the IL-6 family of cytokines which also includes LIF, CNTF, OSM (Oncostatin M), IL-11, IL-6 and possibly NNT-1/ BCSF-3. CT-1 is a pleiotropic cytokine which is expressed in various tissues including the adult heart, skeletal muscle, ovary, colon, prostate and fetal lung and signals through the LIF receptor and the gp130 receptor subunit. CT-1 has the ability to induce cardiac myocyte hypertrophy, and enhances the survival of cardiomyocyte and different neuronal populations.
• Source: E.coli.
• Purity: >98% (SDS-PAGE; HPLC).
• Endotoxin Level: <0.1ng per μg ofCardiotrophin 1.
• Stabilizer: None.
• Formulation: Lyophilized.
• Biologically Activity: The ED50 as determined by the dose-dependent proliferation of TF-1 cells was <1.0ng/ml, corresponding to a specific activity of >1x106 units/mg.
• Reconstitution: The murine Cardiotrophin-1 should be reconstituted in water to a concentration of 0.1-1.0mg/ml. This solution can be diluted in water or other buffer solutions or stored at -20°C.
• Stability: The lyophilized protein is stable for a few weeks at room temperature, but best stored at -20°C. Reconstituted murine Cardiotrophin-1 should be stored in working aliquots at -20°C. Avoid repeated freeze-thaw cycles.

Gene Information

• Gene Name: Ctf1 cardiotrophin 1 [ Mus musculus ]
• Synonyms: Ctf1; cardiotrophin 1; CT-1; cardiotrophin-1
• Gene ID: 13019
• mRNA Refseq: NM_007795
• Protein Refseq: NP_031821
• UniProt ID: Q60753
• Chromosome Location: 7
• Pathway: Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway
• Function: cytokine activity