"TFF3" Related Products

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Recombinant Human Trefoil Factor 3

Cat. No.: TFF3-973H
Product Overview: Recombinant human TFF3 produced inE.coliis a 13.2 kDa homodimeric protein consisting of two 59 amino acid chains, which includes a 40-amino acid trefoil motif containing three conserved intramolecular disulfide bonds.
Description: The Trefoil Factor peptides (TFF1, TFF2 and TFF3) are secreted in the gastrointestinal tract, and appear to play an important role in intestinal mucosal defense and repair. TFF-3 is expressed by goblet cells and in the uterus, and has also been shown to express in certain cancers, including colorectal, hepatocellular, and in biliary tumors. TFF3 may be useful as a molecular marker for certain types of cancer, but its role, if any, in tumorigenesis is unknown. TFF3 also promotes airway epithelial cell migration and differentiation.
Source: E.coli.
Purity: > 98% by SDS-PAGE analyses.
Endotoxin Level: < 0.1 ng per ug of TFF-3.
Stabilizer: None.
Formulation: Lyophilized.
Biological Activity: Determined by its ability to chemoattract human MCF-7 cells using a concentration range of 1.0-10.0 μg/ml.
Stability: The lyophilized protein is stable for at least 2 years from date of receipt at -20℃. Reconstituted TFF-3 is stable for at least 3 months when stored in working aliquots with a carrier protein at-20℃. Avoid repeated freeze-thaw cycles.
Gene Name: TFF3 trefoil factor 3 (intestinal) [ Homo sapiens ]
Synonyms: TFF3; trefoil factor 3 (intestinal); ITF; TFI; HITF; hP1.B; Intestinal trefoil factor; Polypeptide P1.B; secretory protein; trefoil factor 3; trefoil factor 3, HITF, human intestinal trefoil factor; Trefoil factor 3
Gene ID: 7033
mRNA Refseq: NM_003226
Protein Refseq: NP_003217
MIM: 600633
UniProt ID: Q07654
Chromosome Location: 21q22.3
Function: chromatin binding; protein binding; sequence-specific DNA binding; transcription factor activity

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