"ITK" Related Products


Recombinant Human IL2-inducible T-cell Kinase, GST-tagged, Active

Cat. No. : ITK-335H
Product Overview : Recombinant human ITK (352-end) was expressed by baculovirus inSf9 insect cellsusing an N-terminal GST tag. MW = 53 kDa.
Description : ITK is a member of the TEC family of non-receptor tyrosine kinases. ITK is expressed in T-cells and is important for T-cell development and activation through the antigen receptor. ITK require prior activation of Lck, Zap-70 and PI3-kinase for efficient activation and shares major substrates with both Lck and Zap-70. ITK knockout mice show multiple effects on T cell development, cytokine production and T-helper cell differentiation. T cells that lack or express mutant versions of ITK show impaired TCR-induced actin polymerization, cell polarization and regulation of the signaling events involved in cytoskeletal reorganization.
Source : Sf9 insect cells using baculovirus.
Sequence : 352-end.
Applications : Kinase Assay, Western Blot.
Storage And Stability : Store product at -70℃. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Gene Name : ITK IL2-inducible T-cell kinase [ Homo sapiens ]
Synonyms : ITK; IL2-inducible T-cell kinase; EMT; LYK; PSCTK2; MGC126257; MGC126258; tyrosine-protein kinase LYK; homolog of mouse T-cell itk/tsk; tyrosine-protein kinase ITK/TSK; EC; Kinase EMT
Gene ID : 3702
mRNA Refseq : NM_005546
Protein Refseq : NP_005537
MIM : 186973
UniProt ID : Q08881
Chromosome Location : 5q31-q32
Pathway : Chemokine signaling pathway; Leukocyte transendothelial migration; T cell receptor signaling pathway
Function : ATP binding; metal ion binding; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; protein binding; transferase activity; zinc ion binding

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