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Recombinant Human ANGPTL3, FLAG-tagged

Cat.No.: ANGPTL3-27353TH
Product Overview: Recombinant fragment corresponding to amino acids 224-460 of Human ANGPTL3 with an N terminal DDDDK tag; MWt 35 kDa by SDS PAGE.
Description: The protein encoded by this gene is a member of the angiopoietin-like family of secreted factors. It is predominantly expressed in the liver, and has the characteristic structure of angiopoietins, consisting of a signal peptide, N-terminal coiled-coil domain and the C-terminal fibrinogen (FBN)-like domain. The FBN-like domain in angiopoietin-like 3 protein was shown to bind alpha-5/beta-3 integrins, and this binding induced endothelial cell adhesion and migration. This protein may also play a role in the regulation of angiogenesis.
Protein length: 237 amino acids
Conjugation: FLAG
Molecular Weight: 35.000kDa inclusive of tags
Source: HEK 293 cells
Tissue specificity: Expressed principally in liver. Weakly expressed in kidney.
Form: Liquid
Purity: >90% by SDS-PAGE
Storage buffer: Preservative: NoneConstituents: PBS
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Sequence Similarities: Contains 1 fibrinogen C-terminal domain.
Gene Name: ANGPTL3 angiopoietin-like 3 [ Homo sapiens ]
Official Symbol: ANGPTL3
Synonyms: ANGPTL3; angiopoietin-like 3; ANGPT5; angiopoietin-related protein 3; angiopoietin 5;
Gene ID: 27329
mRNA Refseq: NM_014495
Protein Refseq: NP_055310
MIM: 604774
Uniprot ID: Q9Y5C1
Chromosome Location: 1p31.1-p22.3
Pathway: Integrins in angiogenesis, organism-specific biosystem;
Function: cell surface binding; enzyme inhibitor activity; growth factor activity; integrin binding; phospholipase inhibitor activity;

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