Recombinant Human BIRC2

• Cat.No.: BIRC2-27192TH
• Product Overview: Recombinant full length Human cIAP1 with an N terminal proprietary tag; predicted mwt: 94.05 kDa inclusive of tag.

Specification

• Description: The protein encoded by this gene is a member of a family of proteins that inhibits apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. This encoded protein inhibits apoptosis induced by serum deprivation and menadione, a potent inducer of free radicals.
• Protein length: 618 amino acids
• Molecular Weight: 94.050kDa
• Source: Wheat germ
• Tissue specificity: Present in many fetal and adult tissues. Mainly expressed in adult skeletal muscle, thymus, testis, ovary, and pancreas, low or absent in brain and peripheral blood leukocytes.
• Form: Liquid
• Purity: Proprietary Purification
• Storage buffer: pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: MHKTASQRLFPGPSYQNIKSIMEDSTILSDWTNSNKQKMK YDFSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDK VKCFCCGLMLDNWKLGDSPIQKHKQLYPSCSFIQNLVSAS LGSTSKNTSPMRNSFAHSLSPTLEHSSLFSGSYSSLSPNP LNSRAVEDISSSRTNPYSYAMSTEEARFLTYHMWPLTFLS PSELARAGFYYIGPGDRVACFACGGKLSNWEPKDDAMSEH RRHFPNCPFLENSLETLRFSISNLSMQTHAARMRTFMYWP SSVPVQPEQLASAGFYYVGRNDDVKCFCCDGGLRCWESGD DPWVEHAKWFPRCEFLIRMKGQEFVDEIQGRYPHLLEQLL STSDTTGEENADPPIIHFGPGESSSEDAVMMNTPVVKSAL EMGFNRDLVKQTVQSKILTTGENYKTVNDIVSALLNAEDE KREEEKEKQAEEMASDDLSLIRKNRMALFQQLTCVLPILD NLLKANVINKQEHDIIKQKTQIPLQARELIDTILVKGNAA ANIFKNCLKEIDSTLYKNLFVDKNMKYIPTEDVSGLSLEE QLRRLQEERTCKVCMDKEVSVVFIPCGHLVVCQECAPSLR KCPICRGIIKGTVRTFLS
• Sequence Similarities: Belongs to the IAP family.Contains 3 BIR repeats.Contains 1 CARD domain.Contains 1 RING-type zinc finger.

Gene Information

• Gene Name: BIRC2 baculoviral IAP repeat containing 2 [ Homo sapiens ]
• Official Symbol: BIRC2
• Synonyms: BIRC2; baculoviral IAP repeat containing 2; API1, baculoviral IAP repeat containing 2; baculoviral IAP repeat-containing protein 2; apoptosis inhibitor 1; c IAP1; cIAP1; hiap 2; MIHB; NFR2 TRAF signalling complex protein; RNF48
• Gene ID: 329
• mRNA Refseq: NM_001166
• Protein Refseq: NP_001157
• MIM: 601712
• Uniprot ID: Q13490
• Chromosome Location: 11q22
• Pathway: Apoptosis, organism-specific biosystem; Apoptosis, organism-specific biosystem; Apoptosis, conserved biosystem; Apoptosis, organism-specific biosystem; Apoptotic cleavage of cellular proteins, organism-specific biosystem
• Function: metal ion binding; protein N-terminus binding; protein binding; ubiquitin-protein ligase activity; zinc ion binding