Recombinant Human CFL1 CFL1-26781TH

Recombinant Human CFL1

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Recombinant Human CFL1

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Cat.No. : CFL1-26781TH
Product Overview : Recombinant full length protein, corresponding to amino acids 2-166 of Human Cofilin, with an N terminal proprietary tag. Predicted molecular weight: 44 kDa;
Description : The protein encoded by this gene can polymerize and depolymerize F-actin and G-actin in a pH-dependent manner. Increased phosphorylation of this protein by LIM kinase aids in Rho-induced reorganization of the actin cytoskeleton. Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus.
Source : E. coli
Tissue specificity : Widely distributed in various tissues.
Form : Liquid
Purity : >90% by SDS-PAGE
Storage buffer : Preservative: NoneConstituents: 30% Glycerol, 0.05% Tween 20, 3mM DTT, 25mM Tris HCl, 100mM Sodium chloride, pH 8.0
Storage : Shipped at 4°C. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequence Similarities : Belongs to the actin-binding proteins ADF family.Contains 1 ADF-H domain.
Gene Name : CFL1 cofilin 1 (non-muscle) [ Homo sapiens ]
Official Symbol : CFL1
Synonyms : CFL1; cofilin 1 (non-muscle); CFL; cofilin-1;
Gene ID : 1072
mRNA Refseq : NM_005507
Protein Refseq : NP_005498
MIM : 601442
Uniprot ID : P23528
Chromosome Location : 11q13.1
Pathway : Axon guidance, organism-specific biosystem; Axon guidance, conserved biosystem; Axon guidance, organism-specific biosystem; CDC42 signaling events, organism-specific biosystem; CXCR4-mediated signaling events, organism-specific biosystem;
Function : actin binding; protein binding;

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