Recombinant Human CFL1


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Recombinant Human CFL1

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Cat.No. : CFL1-26781TH
Product Overview : Recombinant full length protein, corresponding to amino acids 2-166 of Human Cofilin, with an N terminal proprietary tag. Predicted molecular weight: 44 kDa;
Description : The protein encoded by this gene can polymerize and depolymerize F-actin and G-actin in a pH-dependent manner. Increased phosphorylation of this protein by LIM kinase aids in Rho-induced reorganization of the actin cytoskeleton. Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus.
Source : E. coli
Tissue specificity : Widely distributed in various tissues.
Form : Liquid
Purity : >90% by SDS-PAGE
Storage buffer : Preservative: NoneConstituents: 30% Glycerol, 0.05% Tween 20, 3mM DTT, 25mM Tris HCl, 100mM Sodium chloride, pH 8.0
Storage : Shipped at 4°C. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequence Similarities : Belongs to the actin-binding proteins ADF family.Contains 1 ADF-H domain.
Gene Name : CFL1 cofilin 1 (non-muscle) [ Homo sapiens ]
Official Symbol : CFL1
Synonyms : CFL1; cofilin 1 (non-muscle); CFL; cofilin-1;
Gene ID : 1072
mRNA Refseq : NM_005507
Protein Refseq : NP_005498
MIM : 601442
Uniprot ID : P23528
Chromosome Location : 11q13.1
Pathway : Axon guidance, organism-specific biosystem; Axon guidance, conserved biosystem; Axon guidance, organism-specific biosystem; CDC42 signaling events, organism-specific biosystem; CXCR4-mediated signaling events, organism-specific biosystem;
Function : actin binding; protein binding;
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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