Recombinant Human ERCC1

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Recombinant Human ERCC1

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Cat.No. : ERCC1-28691TH
Product Overview : Recombinant full length human ERCC1 with proprietary tag; amino acids 1-297, 61kDa.
Description : The product of this gene functions in the nucleotide excision repair pathway, and is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. The encoded protein forms a heterodimer with the XPF endonuclease (also known as ERCC4), and the heterodimeric endonuclease catalyzes the 5 incision in the process of excising the DNA lesion. The heterodimeric endonuclease is also involved in recombinational DNA repair and in the repair of inter-strand crosslinks. Mutations in this gene result in cerebrooculofacioskeletal syndrome, and polymorphisms that alter expression of this gene may play a role in carcinogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. The last exon of this gene overlaps with the CD3e molecule, epsilon associated protein gene on the opposite strand.
Source : E. coli
Form : Liquid
Storage buffer : Preservative: NoneConstituents: 20% Glycerol, 50mM Tris acetate, 1mM EDTA, pH 7.5
Storage : Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Sequence Similarities : Belongs to the ERCC1/RAD10/SWI10 family.
Gene Name : ERCC1 excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence) [ Homo sapiens ]
Official Symbol : ERCC1
Synonyms : ERCC1; excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence); DNA excision repair protein ERCC-1; RAD10;
Gene ID : 2067
mRNA Refseq : NM_001166049
Protein Refseq : NP_001159521
MIM : 126380
Uniprot ID : P07992
Chromosome Location : 19q13.32
Pathway : DNA Repair, organism-specific biosystem; Dual incision reaction in GG-NER, organism-specific biosystem; Dual incision reaction in TC-NER, organism-specific biosystem; Fanconi anemia pathway, organism-specific biosystem; Fanconi anemia pathway, conserved biosystem;
Function : damaged DNA binding; damaged DNA binding; endonuclease activity; hydrolase activity; protein C-terminus binding;

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