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| Cat. No.: | Bmpr1a-1709M |
| Description: | Cellular responses to bone morphogenetic proteins (BMPs) have been shown to be mediated by the formation of hetero-oligomeric complexes of the type I and type II serine/threonine kinase receptors. BMP receptor 1A (BMPR-1A), also known as activin receptor-like kinase (ALK)-3, is a monomeric glycoprotein and is a one of seven known type I serine/threonine kinases that are required for the signal transduction of TGF-β family cytokines. Human and mouse BMPR-IA are highly conserved and share 98% sequence identity. BMPRIA immunohistochemistry may be a promising new tool for the identification of enteric ganglion cells in the evaluation of patients with neurointestinal disorders. |
| Molecular Weight: | The predicted molecular weight of Recombinant Mouse BMPR-IA is Mr 41.5 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 55 kDa. |
| Source: | NSO Cells. |
| State Of Matter: | Lyophilized. |
| Purity: | >95% by SDS Page and analyzed by silver stain. |
| Endotoxin: | <1.0 EU/µg as determined by the LAL method. |
| Storage And Stability: | This lyophilized protein is stable for six to twelve months when stored desiccated at -20℃ to -70℃. After aseptic reconstitution, this protein may be stored at 2℃ to 8℃ for one month or at -20℃ to -70℃ in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions. |
| Gene Name: | Bmpr1a bone morphogenetic protein receptor, type 1A [ Mus musculus ] |
| Synonyms: | Bmpr1a; bone morphogenetic protein receptor, type 1A; ALK3; Bmpr; BMPR-IA; AU045487; 1110037I22Rik; EC 2.7.11.1; EC 2.7.11.30 |
| Gene ID: | 12166 |
| mRNA Refseq: | NM_009758 |
| Protein Refseq: | NP_033888 |
| UniProt ID: | P36895 |
| Chromosome Location: | 14 B; 14 13.0 cM |
| Pathway: | Cytokine-cytokine receptor interaction; TGF-beta signaling pathway |
| Function: | ATP binding; kinase activity; magnesium ion binding; manganese ion binding; metal ion binding; nucleotide binding; protein kinase activity; protein serine/threonine kinase activity; receptor activity; transferase activity; transforming growth factor beta receptor activity; transmembrane receptor protein serine/threonine kinase activity |
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