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Recombinant Mouse Bone Morphogenetic Protein Receptor, Type 1A

Cat.No. : Bmpr1a-1709M
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Cat. No. : Bmpr1a-1709M
Description : Cellular responses to bone morphogenetic proteins (BMPs) have been shown to be mediated by the formation of hetero-oligomeric complexes of the type I and type II serine/threonine kinase receptors. BMP receptor 1A (BMPR-1A), also known as activin receptor-like kinase (ALK)-3, is a monomeric glycoprotein and is a one of seven known type I serine/threonine kinases that are required for the signal transduction of TGF-β family cytokines. Human and mouse BMPR-IA are highly conserved and share 98% sequence identity. BMPRIA immunohistochemistry may be a promising new tool for the identification of enteric ganglion cells in the evaluation of patients with neurointestinal disorders.
Molecular Weight : The predicted molecular weight of Recombinant Mouse BMPR-IA is Mr 41.5 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 55 kDa.
Source : Mammalian cells
State Of Matter : Lyophilized.
Purity : >95% by SDS Page and analyzed by silver stain.
Endotoxin : <1.0 EU/µg as determined by the LAL method.
Storage And Stability : This lyophilized protein is stable for six to twelve months when stored desiccated at -20℃ to -70℃. After aseptic reconstitution, this protein may be stored at 2℃ to 8℃ for one month or at -20℃ to -70℃ in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Gene Name : Bmpr1a bone morphogenetic protein receptor, type 1A [ Mus musculus ]
Synonyms : Bmpr1a; bone morphogenetic protein receptor, type 1A; ALK3; Bmpr; BMPR-IA; AU045487; 1110037I22Rik; EC 2.7.11.1; EC 2.7.11.30
Gene ID : 12166
mRNA Refseq : NM_009758
Protein Refseq : NP_033888
UniProt ID : P36895
Chromosome Location : 14 B; 14 13.0 cM
Pathway : Cytokine-cytokine receptor interaction; TGF-beta signaling pathway
Function : ATP binding; kinase activity; magnesium ion binding; manganese ion binding; metal ion binding; nucleotide binding; protein kinase activity; protein serine/threonine kinase activity; receptor activity; transferase activity; transforming growth factor beta receptor activity; transmembrane receptor protein serine/threonine kinase activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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What disease might abnormal BMPR1A levels suggest? 11/20/2022

Abnormal levels of BMPR1A may suggest skeletal dysplasia, tumors, etc., but its specificity and sensitivity need to be further studied.

Is there a mutation type of BMPR1A? 10/12/2022

The types of mutations in BMPR1A include point mutations, insertions/deletions, duplications, etc., which may cause structural and functional abnormalities of the protein.

How are mutations in BMPR1A detected and analyzed? 01/05/2022

Mutations in BMPR1A can be detected and analyzed by methods such as whole-genome sequencing or target region sequencing to understand the impact of mutations on protein structure and function.

How to study the regulatory mechanism of BMPR1A? 01/03/2022

Studying the regulatory mechanism of BMPR1A requires a comprehensive use of various experimental methods and techniques, such as gene knockout, transcriptome analysis, and protein-protein interactions.

What are the applications of BMPR1A in medical treatment? 03/10/2020

BMPR1A can be used as a biomarker in medical treatment to help monitor disease progression and treatment efficacy. In addition, therapeutics targeting BMPR1A, such as gene therapy or modulating its expression, are also being studied.

What diseases can BMPR1A deficiency or aberrant expression cause? 01/21/2020

Deficiency or abnormal expression of BMPR1A may be related to some skeletal dysplasia diseases, tumors, etc.

Customer Reviews (3)

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Reviews
11/06/2021

    The enzyme activity of this protein reached the expected level and was able to play a role in the specific reaction.

    10/20/2021

      When experimenting with this protein, stable and repeatable results can be obtained.

      03/08/2021

        This product has strict quality control and complies with relevant industry standards.

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