Recombinant Human BMPR1A protein(Met1-Arg152), hFc-tagged
Cat.No. : | BMPR1A-2931H |
Product Overview : | Recombinant Human BMPR1A (NP_004320.2) (Met1-Arg152) was expressed in HEK293 with the Fc region of Human IgG1 at the C-terminus. |
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Source : | HEK293 |
Species : | Human |
Tag : | Fc |
Protein length : | Met1-Arg152 |
Form : | Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. |
Bio-activity : | Measured by its ability to inhibit BMP4-induced alkaline phosphatase production by MC3T3-E1 cells. The ED50 for this effect is typically 25-100 ng/mL in the presence of 25 ng/mL of hBMP4. |
Molecular Mass : | The recombinant human BMPR1A consists of 367 amino acids and predicts a molecular mass of 40.9 kDa. |
Endotoxin : | < 1.0 EU per μg protein as determined by the LAL method. |
Purity : | > 95 % as determined by SDS-PAGE. |
Storage : | Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents. |
Gene Name : | BMPR1A bone morphogenetic protein receptor, type IA [ Homo sapiens ] |
Official Symbol : | BMPR1A |
Synonyms : | BMPR1A; bone morphogenetic protein receptor, type IA; ACVRLK3; bone morphogenetic protein receptor type-1A; ALK3; CD292; ALK-3; BMPR-1A; BMP type-1A receptor; activin receptor-like kinase 3; activin A receptor, type II-like kinase 3; serine/threonine-protein kinase receptor R5; SKR5; 10q23del; |
Gene ID : | 657 |
mRNA Refseq : | NM_004329 |
Protein Refseq : | NP_004320 |
MIM : | 601299 |
UniProt ID : | P36894 |
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◆ Lysates | ||
BMPR1A-2466MCL | Recombinant Mouse BMPR1A cell lysate | +Inquiry |
BMPR1A-2145HCL | Recombinant Human BMPR1A cell lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Customer Reviews (3)
Write a reviewThe enzyme activity of this protein reached the expected level and was able to play a role in the specific reaction.
When experimenting with this protein, stable and repeatable results can be obtained.
This product has strict quality control and complies with relevant industry standards.
Q&As (6)
Ask a questionAbnormal levels of BMPR1A may suggest skeletal dysplasia, tumors, etc., but its specificity and sensitivity need to be further studied.
The types of mutations in BMPR1A include point mutations, insertions/deletions, duplications, etc., which may cause structural and functional abnormalities of the protein.
Mutations in BMPR1A can be detected and analyzed by methods such as whole-genome sequencing or target region sequencing to understand the impact of mutations on protein structure and function.
Studying the regulatory mechanism of BMPR1A requires a comprehensive use of various experimental methods and techniques, such as gene knockout, transcriptome analysis, and protein-protein interactions.
BMPR1A can be used as a biomarker in medical treatment to help monitor disease progression and treatment efficacy. In addition, therapeutics targeting BMPR1A, such as gene therapy or modulating its expression, are also being studied.
Deficiency or abnormal expression of BMPR1A may be related to some skeletal dysplasia diseases, tumors, etc.
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