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Recombinant Human FADD, His-tagged

Cat.No.: FADD-28817TH
Product Overview: Recombinant full length human FADD with His tag; amino acids 1-208 , 27.4kDa.
Description: The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development.
Conjugation: HIS
Source: E. coli
Tissue specificity: Expressed in a wide variety of tissues, except for peripheral blood mononuclear leukocytes.
Form: Liquid
Purity: >95% by SDS-PAGE
Storage buffer: Preservative: NoneConstituents: 10% Glycerol, 20mM Tris HCl, pH 8.0
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Sequence Similarities: Contains 1 death domain.Contains 1 DED (death effector) domain.
Gene Name: FADD Fas (TNFRSF6)-associated via death domain [ Homo sapiens ]
Official Symbol: FADD
Synonyms: FADD; Fas (TNFRSF6)-associated via death domain; protein FADD; Fas associating death domain containing protein; Fas associating protein with death domain; GIG3; growth inhibiting gene 3 protein; mediator of receptor induced toxicity; MORT1;
Gene ID: 8772
mRNA Refseq: NM_003824
Protein Refseq: NP_003815
MIM: 602457
Uniprot ID: Q13158
Chromosome Location: 11q13.3
Pathway: Activation of Pro-Caspase 8, organism-specific biosystem; Alzheimers disease, organism-specific biosystem; Alzheimers disease, conserved biosystem; Apoptosis, organism-specific biosystem; Apoptosis, organism-specific biosystem;
Function: death receptor binding; identical protein binding; protein binding; tumor necrosis factor receptor binding; tumor necrosis factor receptor superfamily binding;

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