Recombinant Human FADD, His-tagged

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Recombinant Human FADD, His-tagged

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Cat.No. : FADD-28817TH
Product Overview : Recombinant full length human FADD with His tag; amino acids 1-208 , 27.4kDa.
Description : The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development.
Conjugation : HIS
Source : E. coli
Tissue specificity : Expressed in a wide variety of tissues, except for peripheral blood mononuclear leukocytes.
Form : Liquid
Purity : >95% by SDS-PAGE
Storage buffer : Preservative: NoneConstituents: 10% Glycerol, 20mM Tris HCl, pH 8.0
Storage : Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Sequence Similarities : Contains 1 death domain.Contains 1 DED (death effector) domain.
Gene Name : FADD Fas (TNFRSF6)-associated via death domain [ Homo sapiens ]
Official Symbol : FADD
Synonyms : FADD; Fas (TNFRSF6)-associated via death domain; protein FADD; Fas associating death domain containing protein; Fas associating protein with death domain; GIG3; growth inhibiting gene 3 protein; mediator of receptor induced toxicity; MORT1;
Gene ID : 8772
mRNA Refseq : NM_003824
Protein Refseq : NP_003815
MIM : 602457
Uniprot ID : Q13158
Chromosome Location : 11q13.3
Pathway : Activation of Pro-Caspase 8, organism-specific biosystem; Alzheimers disease, organism-specific biosystem; Alzheimers disease, conserved biosystem; Apoptosis, organism-specific biosystem; Apoptosis, organism-specific biosystem;
Function : death receptor binding; identical protein binding; protein binding; tumor necrosis factor receptor binding; tumor necrosis factor receptor superfamily binding;
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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