"IL1R1" Related Products


Recombinant Human Interleukin 1 Receptor, Type I

Cat. No. : IL1R1-1640H
Description : Interleukin 1 receptor, type I (IL1R1), also known as CD121a (Cluster of Differentiation 121a, is a master regulator of inflammation and innate immunity. When triggered by IL-1beta, IL-1RI aggregates with IL-1R-associated protein (IL-1RAcP) and forms a membrane proximal signalosome that potently activates downstream signaling cascades. IL1R1 is expressed predominantly by T cells, fibroblasts, and endothelial cells.
Source : NSO Cells.
State Of Matter : Lyophilized.
Purity : >97% by SDS Page and analyzed by silver stain.
Endotoxin : <1.0 EU/µg as determined by the LAL method.
Molecular Weight : The predicted molecular weight of Recombinant Human IL-1 sRI is Mr 36 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 55 kDa.
Storage And Stability : This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
PDB rendering based on 1g0y. :

Gene Name : IL1R1 interleukin 1 receptor, type I [ Homo sapiens ]
Synonyms : IL1R1; interleukin 1 receptor, type I; P80; IL1R; IL1RA; CD121A; D2S1473; IL-1R-alpha; p80; antigen CD121a; OTTHUMP00000161344; interleukin receptor 1; interleukin 1 receptor alpha, type I; Interleukin-1 receptor type I; IL-1R-1; IL-1RT1; CD121 antigen-like family member A; CD121a antigen
Gene ID : 3554
mRNA Refseq : NM_000877
Protein Refseq : NP_000868
MIM : 147810
UniProt ID : P14778
Chromosome Location : 2q12
Pathway : Apoptosis; Cytokine-cytokine receptor interactioN; Hematopoietic cell lineage; MAPK signaling pathway
Function : interleukin-1, Type I, activating receptor activity TAS; platelet-derived growth factor receptor binding; protein binding; transmembrane receptor activity

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