Expand Expand| Cat. No. : | KDR-1697H |
| Product Overview : | Recombinant Human VEGFR2 encoding amino acid residues 1 - 764 of the extracellular domain of human VEGFR2 was fused to a 6X His-tagged Fc of human IgG1 via the peptide (IEGRMD). It was expressed inNSO Cells. |
| Description : | Vascular endothelial growth factor receptor 2 (VEGF R2) is a transmembrane glycoprotein that is a member of a receptor tyrosine kinase family whose activation plays an essential role in a large number of biological processes such as embryonic development, wound healing, cell proliferation, migration, and differentiation. |
| Source : | NSO Cells. |
| State Of Matter : | Lyophilized. |
| Purity : | >90% by SDS Page and analyzed by silver stain. |
| Endotoxin : | <1.0 EU/µg as determined by the LAL method. |
| Molecular Weight : | The predicted molecular weight of Recombinant Human KDR is Mr 110 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 160-170 kDa. |
| Biological Activity : | The biological activity of Human KDR was determined by its ability to inhibit the VEGF-dependent proliferation of human umbilical vein endothelial cells. The expected ED50 for this effect is typically 4-8 ng/ml in the presence of 5 ng/ml recombinant human VEGF165. |
| Storage And Stability : | This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. |
| Gene Name : | KDR kinase insert domain receptor (a type III receptor tyrosine kinase) [ Homo sapiens ] |
| Synonyms : | KDR; kinase insert domain receptor (a type III receptor tyrosine kinase); FLK1; CD309; VEGFR; VEGFR2; Vascular endothelial growth factor receptor 2; VEGFR-2; Kinase insert domain receptor; Protein-tyrosine kinase receptor Flk-1; EC 2.7.10.1; fetal liver kinase-1; soluble VEGFR2; tyrosine kinase growth factor receptor |
| Gene ID : | 3791 |
| mRNA Refseq : | NM_002253 |
| Protein Refseq : | NP_002244 |
| MIM : | 191306 |
| UniProt ID : | P35968 |
| Chromosome Location : | 4q11-q12 |
| Pathway : | Cytokine-cytokine receptor interaction; Endocytosis; Focal adhesion; VEGF signaling pathway; Signaling by VEGF |
| Function : | ATP binding; growth factor binding; nucleotide binding; receptor activity; transferase activity; vascular endothelial growth factor receptor activity |
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