Recombinant Human PMEL PMEL-30194TH

Recombinant Human PMEL

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Recombinant Human PMEL

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Cat.No. : PMEL-30194TH
Product Overview : Recombinant fragment, corresponding to amino acids 1-150 of Human Melanoma gp100
Description : This gene encodes a melanocyte-specific type I transmembrane glycoprotein. The encoded protein is enriched in melanosomes, which are the melanin-producing organelles in melanocytes, and plays an essential role in the structural organization of premelanosomes. This protein is involved in generating internal matrix fibers that define the transition from Stage I to Stage II melanosomes. This protein undergoes a complex pattern of prosttranslational processing and modification that is essential to the proper functioning of the protein. A secreted form of this protein that is released by proteolytic ectodomain shedding may be used as a melanoma-specific serum marker. Alternate splicing results in multiple transcript variants.
Source : E. coli
Tissue specificity : Preferentially expressed in melanomas. Some expression was found in dysplastic nevi. Not found in normal tissues nor in carcinomas. Normally expressed at low levels in quiescent adult melanocytes but overexpressed by proliferating neonatal melanocytes and
Form : Liquid
Purity : Purified via GST Tag
Storage buffer : Preservative: NoneConstituents: 20% Glycerol, 50mM Tris acetate, 1mM EDTA, pH 7.5
Storage : Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Sequence Similarities : Belongstot hePMEL/NMB family.Con tains1PKDd omain.
Gene Name : PMEL premelanosome protein [ Homo sapiens ]
Official Symbol : PMEL
Synonyms : PMEL; premelanosome protein; SIL, SILV, silver (mouse homolog) like , silver homolog (mouse); melanocyte protein PMEL; D12S53E; gp100; Pmel17; SI;
Gene ID : 6490
mRNA Refseq : NM_001200053
Protein Refseq : NP_001186982
MIM : 155550
Uniprot ID : P40967
Chromosome Location : 12q13-q14
Function : protein binding;

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