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Recombinant Human Fibroblast Activation Protein, Alpha, His-tagged

Cat. No.: FAP-426H
Product Overview: Recombinant human FAP (amino acids 29-end) with C-terminal His tag, MW=85.5 kDa, expressed in aBaculovirus infected Sf9cell expression system.
Description: Fibroblast activation protein, alpha, also known as FAP, is a human gene and encodes for a protease. The protein encoded by this gene is a homodimeric integral membrane gelatinase belonging to the serine protease family. It is selectively expressed in reactive stromal fibroblasts of epithelial cancers, granulation tissue of healing wounds, and malignant cells of bone and soft tissue sarcomas. This protein is thought to be involved in the control of fibroblast growth or epithelial-mesenchymal interactions during development, tissue repair, and epithelial carcinogenesis.
Source: Baculovirus infected Sf9 cells.
Application: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Fomulated In: 25 mM Tris-HCl, pH 8.0, 100 mM NaCl, 0.05% Tween-20, 50% glycerol, and 3 mM DTT.
Purity: >90%.
Stability:: >6 months at -80°C.
Gene Name: FAP fibroblast activation protein, alpha [ Homo sapiens ]
Synonyms: FAP; fibroblast activation protein, alpha; DPPIV; seprase; Integral membrane serine protease; 170 kDa melanoma membrane-bound gelatinase; DKFZp686G13158; EC 3.4.21;FAPA; Fibroblast activation protein alpha
Gene ID: 2191
mRNA Refseq: NM_004460
Protein Refseq: NP_004451
MIM: 600403
UniProt ID: Q12884
Chromosome Location: 2q23
Function: dipeptidyl-peptidase activity; metalloendopeptidase activity; peptidase activity; protein homodimerization activity; serine-type endopeptidase activity

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