FAP

  • Official Full Name

    fibroblast activation protein, alpha

  • Overview

    The protein encoded by this gene is a homodimeric integral membrane gelatinase belonging to the serine protease family. It is selectively expressed in reactive stromal fibroblasts of epithelial cancers, granulation tissue of healing wounds, and malignant cells of bone and soft tissue sarcomas. This protein is thought to be involved in the control of fibroblast growth or epithelial-mesenchymal interactions during development, tissue repair, and epithelial carcinogenesis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2014]
  • Synonyms

    FAP; fibroblast activation protein, alpha; FAPA; DPPIV; seprase; integral membrane serine protease; 170 kDa melanoma membrane-bound gelatinase;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Chicken
  • Cynomolgus
  • Human
  • Monkey
  • Mouse
  • Rat
  • CHO
  • E.coli
  • HEK293
  • HEK293F
  • HEK293T
  • Human
  • Human Cell
  • Human Cells
  • In Vitro Cell Free System
  • Insect Cell
  • Insect cells
  • Mammalian cells
  • NS0
  • Sf9 Insect Cell
  • Wheat Germ
  • C
  • His
  • DYKDDDDK
  • Fc
  • Flag
  • GST
  • hFc
  • His (Fc)
  • Avi
  • SUMO
  • Myc
  • DDK
  • MYC
  • N/A
  • N
  • 6×His
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human FAP-427H Active Recombinant Human FAP protein, His-tagged Insect Cell His Leu26-Asp760
Human FAP-372H Active Recombinant Human FAP Protein, hFc-tagged HEK293 hFc Leu26-Asp760
Human FAP-3836H Recombinant Human FAP Protein, GST-tagged Wheat Germ GST
Human FAP-1461H Recombinant Human fibroblast activation protein, alpha, GST-tagged Human GST
Human FAP-28896TH Recombinant Human FAP E.coli N/A 202 amino acids
Human FAP-426H Recombinant Human Fibroblast Activation Protein, Alpha, His-tagged Sf9 Insect Cell His
Human FAP-1141H Active Recombinant Human FAP, His-tagged HEK293 His Leu26-Asp760
Human FAP-28897TH Recombinant Human FAP, His-tagged His
Human FAP-1881HCL Recombinant Human FAP cell lysate Human Cell N/A
Human FAP-715H Recombinant Human FAP Protein, His-tagged E.coli His Ile523~Asp760
Human FAP-371H Active Recombinant Human FAP Protein, His-tagged HEK293 His Leu26-Asp760
Human FAP-151H Recombinant Human FAP Protein, DYKDDDDK-tagged Human Cells DYKDDDDK
Human FAP-1445H Active Recombinant Human FAP protein, His-tagged, FITC-Labeled HEK293 His Leu26-Asp760
Human FAP-006H Active Recombinant Human FAP Protein, His-tagged Insect cells His
Human FAP-4646HF Recombinant Full Length Human FAP Protein, GST-tagged In Vitro Cell Free System GST 760 amino acids
Human FAP-1141HAF488 Recombinant Human FAP Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His 751
Human FAP-1446H Active Recombinant Human FAP protein, Fc-tagged HEK293 Fc Leu26-Asp760
Human FAP-891H-B Recombinant Human FAP Protein Pre-coupled Magnetic Beads HEK293
Human FAP-589HFL Recombinant Full Length Human FAP Protein, C-Flag-tagged Mammalian cells Flag
Human FAP-891H Recombinant Human FAP Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human FAP-884HB Recombinant Human FAP protein, His-Avi-tagged, Biotinylated HEK293 His-Avi Leu26-Asp760
Human FAP-03H Active Recombinant Human FAP Protein (Leu26-Asp760), N-6×His tagged CHO N-6×His Leu26-Asp760
Human FAP-884H Recombinant Human FAP protein, His-Avi-tagged HEK293 His-Avi It contains Leu26-Asp760.
Human FAP-4806H Active Recombinant Human FAP protein, His-tagged, PE-Labeled HEK293 His Leu 26 - Asp 760
Human FAP-371HB Recombinant Human FAP Protein, His-tagged, Biotinylated HEK293 His Leu26-Asp760
Human FAP-3279H Recombinant Human FAP Protein (Thr38-Leu408), N-His tagged E.coli N-His Thr38-Leu408
Human FAP-3722H Recombinant Human FAP Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human FAP-3281H Recombinant Human FAP Protein (Ile523-Asp760), His tagged E.coli His Ile523-Asp760
Human FAP-2883H Recombinant Human FAP protein, GST-tagged E.coli GST 26-760aa
Human FAP-4101H Recombinant Human FAP Protein (Leu26-Asp760), C-His tagged Mammalian cells C-His Leu26-Asp760
Human FAP-1444H Active Recombinant Human FAP protein, Fc-tagged, FITC-Labeled HEK293 Fc Leu26-Asp760
Human FAP-1141HAF555 Recombinant Human FAP Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His 751
Human FAP-1141HAF647 Recombinant Human FAP Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His 751
Human FAP-1141HF Recombinant Human FAP Protein, His-tagged, FITC conjugated HEK293 His 751
Mouse Fap-32M Active Recombinant Mouse Fap protein Mammalian cells N/A
Mouse FAP-584M Active Recombinant Mouse Fap protein, His-tagged HEK293F His
Mouse Fap-10552M-B Recombinant Mouse Fap Protein Pre-coupled Magnetic Beads HEK293
Mouse Fap-01M Active Recombinant Mouse Fap Protein NS0
Mouse Fap-716M Recombinant Mouse Fap Protein, His-tagged E.coli His Gly542~Asp761
Mouse FAP-321MB Active Recombinant Mouse FAP protein, His-Avi-tagged, Biotinylated HEK293 His-Avi Leu26-Asp761
Mouse Fap-1018M Recombinant Mouse Fap Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse FAP-1443M Active Recombinant Mouse FAP protein, His-tagged HEK293 His Leu26-Asp761
Mouse Fap-2373M Recombinant Mouse Fap protein, His-SUMO-tagged E.coli His-SUMO 26-761aa
Mouse Fap-10552M Recombinant Mouse Fap Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat FAP-1442R Active Recombinant Rat FAP protein, His-tagged HEK293 His Leu26-Asp761
Rat Fap-2764R Recombinant Rat Fap Protein, His-tagged E.coli N-His Gly542-Asp761
Monkey FAP-370CF Active Recombinant Monkeys FAP Protein, His-tagged, FITC conjugated HEK293 His Arg30-Asp760, 750
Monkey FAP-370CAF647 Active Recombinant Monkeys FAP Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His Arg30-Asp760, 750
Monkey FAP-370CAF555 Active Recombinant Monkeys FAP Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His Arg30-Asp760, 750
Monkey FAP-370CAF488 Active Recombinant Monkeys FAP Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His Arg30-Asp760, 750
Cynomolgus FAP-377CB Active Recombinant Cynomolgus FAP protein, His-Avi-tagged, Biotinylated HEK293 His-Avi Leu26-Asp760
Cynomolgus FAP-370C Active Recombinant Cynomolgus FAP protein, His-tagged HEK293 His Leu26-Asp760
Chicken FAP-4123C Recombinant Chicken FAP Protein, K30-E759, N-His tagged HEK293 N-His K30-E759
Kit-1729 FAP Assay Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • FAP Related Articles
  • FAP Related Research Area

FAP involved in several pathways and played different roles in them. We selected most pathways FAP participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with FAP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

FAP has several biochemical functions, for example, dipeptidyl-peptidase activity, endopeptidase activity, integrin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FAP itself. We selected most functions FAP had, and list some proteins which have the same functions with FAP. You can find most of the proteins on our site.

Function Related Protein
dipeptidyl-peptidase activityDPEP1;NAALAD2;DPP4;PRCP;DPEP3;DPP7;DPP3;FAP;DPP8
endopeptidase activityTPP1;SENP3B;ACE;PSMB2;APH1C;FURIN;ADAMTS3;F9;KLK1B11
integrin bindingCD226;VCAM1;ACTN2;TSPAN8;ACTN4;ADAM2;NISCH;ICAM5;KDR
metalloendopeptidase activityPITRM1;MMP24;PAPPAB;YBEY;HE2;MMP16;MIPEP;MMP14B;HE1B
peptidase activityPRSS28;F9A;MMP23BB;PRSS30;C1RA;Ren1;MCPT8;HM13;HTRA1B
protease bindingUBC;CFLAR;CD28;SERPINB3;LCN2;SERPINB6;CD70;COMP;ALPI
protein bindingCELF1;MRPS23;TBX3;CHID1;KIF6;PRTFDC1;OSTA;SECISBP2;AAK1
protein dimerization activityFERD3L;PEF1;DAO1;PRDX5;ASCL1A;NCOA1;DERL3;SRFA;HER11
protein homodimerization activityVOX;CHMP1A;TENM1;SLC26A5;FLT3LG;CADM4;DMRTC1C2;TMEM173;TCF3
serine-type endopeptidase activityTMPRSS11F;C1rb;F9B;PCSK1;MASP1;F2;Prss32;FURIN;HPN
serine-type peptidase activityENDOU;PROCA;HPN;DPP4;ELA3L;ELA2L;PRSS40;HTRA1B;TRY

FAP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FAP here. Most of them are supplied by our site. Hope this information will be useful for your research of FAP.

GCG; VIP; GHRH; NPY; GIP; PYY; NPPB; ADCYAP1; TAC1; b3xyc5_sollc

Rabenhold, M; Steiniger, F; et al. Bispecific single-chain diabody-immunoliposomes targeting endoglin (CD105) and fibroblast activation protein (FAP) simultaneously. JOURNAL OF CONTROLLED RELEASE 201:56-67(2015).
Polites, SF; Zarroug, AE; et al. Single-Incision Laparoscopic Ileal Pouch-Anal Anastomosis in Children-How Does It Compare to a Laparoscopic-Assisted Approach?. JOURNAL OF LAPAROENDOSCOPIC & ADVANCED SURGICAL TECHNIQUES 25:167-171(2015).
  • Q&As
  • Reviews

Q&As (5)

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How does FAP contribute to immunosuppression in the tumor microenvironment? 04/18/2023

FAP can suppress the immune response by modulating the activity of certain immune cells, creating an immunosuppressive tumor microenvironment.

How can FAP expression be used as a prognostic marker in cancer patients? 02/03/2023

High levels of FAP expression in tumors have been associated with poor prognosis, making it a potential prognostic marker for certain cancers.

Are there ongoing clinical trials exploring FAP-targeted therapies? 05/04/2021

Yes, several clinical trials are investigating the safety and efficacy of FAP-targeted therapies in various cancer types.

Can FAP be utilized as a therapeutic target beyond cancer treatment? 11/19/2020

FAP-targeted therapies are being explored for conditions such as fibrotic diseases and rheumatoid arthritis, extending its potential clinical applications.

How is imaging technology utilized to detect FAP expression in tumors? 09/17/2018

Molecular imaging techniques, such as positron emission tomography (PET), can be employed to visualize FAP expression in tumors noninvasively.

Customer Reviews (3)

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Reviews
08/11/2020

    It enables accurate detection and quantification of FAP protein levels in samples, providing crucial insights into its expression, regulation, and potential functional changes under different experimental conditions.

    05/04/2020

      FAP protein is highly recommended for researchers due to its excellent performance in various assays, particularly in Western blotting (WB) experiments, and its applicability in protein electron microscopy structure analysis.

      01/02/2019

        FAP protein is highly recommended for researchers, as it demonstrates excellent performance in WB experiments and has proven useful in protein electron microscopy structure analysis.

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