Official Full Name | fibroblast activation protein, alpha |
Background | The protein encoded by this gene is a homodimeric integral membrane gelatinase belonging to the serine protease family. It is selectively expressed in reactive stromal fibroblasts of epithelial cancers, granulation tissue of healing wounds, and malignant cells of bone and soft tissue sarcomas. This protein is thought to be involved in the control of fibroblast growth or epithelial-mesenchymal interactions during development, tissue repair, and epithelial carcinogenesis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2014] |
Synonyms | FAP; fibroblast activation protein, alpha; FAPA; DPPIV; seprase; integral membrane serine protease; 170 kDa melanoma membrane-bound gelatinase; |
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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FAP involved in several pathways and played different roles in them. We selected most pathways FAP participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with FAP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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FAP has several biochemical functions, for example, dipeptidyl-peptidase activity, endopeptidase activity, integrin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FAP itself. We selected most functions FAP had, and list some proteins which have the same functions with FAP. You can find most of the proteins on our site.
Function | Related Protein |
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dipeptidyl-peptidase activity | DPP8; DPP3; DPP4; NAALAD2; FAP; DPEP1; PRCP; DPEP2; DPP7; DPEP3 |
endopeptidase activity | KLK1B9; PARL; REN2; ACE; RHBDD1; KLK1B22; CPNE1; PSMB4; HTRA3; PSMB2 |
integrin binding | SFRP2; ITGA6; ICAM4; COL3A1; WISP1; CD9; COL5A1; CD226; EMP2; PXN |
metalloendopeptidase activity | TLL2; HE2; MMP25; GM12824; C6AST4; OSGEPL1; PAPPAA; MMP1; C6AST3; MIPEP |
peptidase activity | Casp3; Ctsl; DCD; PRSS42; PRSS28; TMPRSS11G; MMP30; CLCA5; FURIN; USP27X |
protease binding | ECM1; CST3; SERPINA1A; LRP1; CCBE1; ITGB3; MBP; SERPINF2; HSPA6; SERPINA1 |
protein binding | ACE; RRAS2; ITPR1; APOA1; PRMT2; MAPK13; NLGN3; CCDC86; CNKSR3; FBXL12 |
protein dimerization activity | NPAS1; HES6; HER11; PIP4K2AA; EBF1; RIMKLB; ASCL1B; FBXW11B; EBF3A; HER2 |
protein homodimerization activity | CCBL1; VPS25; PYGB; THRA; USF2; CADM2; TP53I3; ARID3A; BOKA; KLHL7 |
serine-type endopeptidase activity | HPR; PRSS45; C2; C1S; KLK1B1; IMMP2L; PRTN3; PRSS21; PCSK7; KLK1B26 |
serine-type peptidase activity | PRSS41; KLK1B8; KLK4; TMPRSS11E; DPP7; ZFYVE9; PRSS59.1; KLK12; TMPRSS13B; PRSS8 |
FAP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FAP here. Most of them are supplied by our site. Hope this information will be useful for your research of FAP.
GCG; VIP; GHRH; NPY; GIP; PYY; NPPB; ADCYAP1; TAC1; b3xyc5_sollc
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