FAP Protein

FAP

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FAP

Official Full Name fibroblast activation protein, alpha
Background The protein encoded by this gene is a homodimeric integral membrane gelatinase belonging to the serine protease family. It is selectively expressed in reactive stromal fibroblasts of epithelial cancers, granulation tissue of healing wounds, and malignant cells of bone and soft tissue sarcomas. This protein is thought to be involved in the control of fibroblast growth or epithelial-mesenchymal interactions during development, tissue repair, and epithelial carcinogenesis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2014]
Synonyms FAP; fibroblast activation protein, alpha; FAPA; DPPIV; seprase; integral membrane serine protease; 170 kDa melanoma membrane-bound gelatinase;
    • Species :
    • Chicken
    • Cynomolgus
    • Human
    • Monkey
    • Mouse
    • Rat
    • Source :
    • E.coli
    • HEK293
    • HEK293F
    • HEK293T
    • Human
    • Human Cell
    • Human Cells
    • In Vitro Cell Free System
    • Insect Cell
    • Insect cells
    • Mammalian Cell
    • Mammalian cells
    • NS0
    • Sf9 Insect Cell
    • Wheat Germ
    • Tag :
    • DYKDDDDK
    • GST
    • hFc
    • His
    • His-Avi
    • His-SUMO
    • Myc/DDK
    • N/A
    • N-His
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse FAP-584M Active Recombinant Mouse Fap protein, His-tagged HEK293F His
    Human FAP-427H Active Recombinant Human FAP protein, His-tagged Insect Cell His
    Mouse Fap-32M Active Recombinant Mouse Fap protein Mammalian cells N/A
    Monkey FAP-370CAF488 Active Recombinant Monkeys FAP Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His
    Monkey FAP-370CAF555 Active Recombinant Monkeys FAP Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His
    Monkey FAP-370CAF647 Active Recombinant Monkeys FAP Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His
    Monkey FAP-370CF Active Recombinant Monkeys FAP Protein, His-tagged, FITC conjugated HEK293 His
    Human FAP-372H Active Recombinant Human FAP Protein, hFc-tagged HEK293 hFc
    Human FAP-1141H Recombinant Human FAP, His tagged Human Cell His
    Human FAP-1461H Recombinant Human fibroblast activation protein, alpha, GST-tagged Human GST
    Human FAP-28896TH Recombinant Human FAP E.coli N/A
    Human FAP-28897TH Recombinant Human FAP, His-tagged His
    Human FAP-3836H Recombinant Human FAP Protein, GST-tagged Wheat Germ GST
    Human FAP-426H Recombinant Human Fibroblast Activation Protein, Alpha, His-tagged Sf9 Insect Cell His
    Chicken FAP-4123C Recombinant Chicken FAP Mammalian Cell His
    Human FAP-1881HCL Recombinant Human FAP cell lysate Human Cell N/A
    Mouse Fap-01M Recombinant Mouse Fap Protein NS0
    Human FAP-1141HAF488 Recombinant Human FAP Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His
    Human FAP-1141HAF555 Recombinant Human FAP Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His
    Human FAP-1141HAF647 Recombinant Human FAP Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His
    Human FAP-1141HF Recombinant Human FAP Protein, His-tagged, FITC conjugated HEK293 His
    Human FAP-151H Recombinant Human FAP Protein, DYKDDDDK-tagged Human Cells DYKDDDDK
    Mouse Fap-2373M Recombinant Mouse Fap protein, His-SUMO-tagged E.coli His-SUMO
    Rat Fap-2764R Recombinant Rat Fap Protein, His-tagged E.coli N-His
    Human FAP-2883H Recombinant Human FAP protein, GST-tagged E.coli GST
    Human FAP-371HB Recombinant Human FAP Protein, His-tagged, Biotinylated HEK293 His
    Human FAP-4646HF Recombinant Full Length Human FAP Protein, GST-tagged In Vitro Cell Free System GST
    Human FAP-006H Recombinant Human FAP Protein, His-tagged Insect cells His
    Human FAP-371H Recombinant Human FAP Protein, His-tagged HEK293 His
    Human FAP-3722H Recombinant Human FAP Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human FAP-715H Recombinant Human FAP Protein, His-tagged E.coli His
    Human FAP-884H Recombinant Human FAP protein, His-Avi-tagged HEK293 His-Avi
    Human FAP-884HB Recombinant Human FAP protein, His-Avi-tagged, Biotinylated HEK293 His-Avi
    Mouse Fap-1018M Recombinant Mouse Fap Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Mouse FAP-321MB Recombinant Mouse FAP protein, His-Avi-tagged, Biotinylated HEK293 His-Avi
    Mouse Fap-716M Recombinant Mouse Fap Protein, His-tagged E.coli His
    Cynomolgus FAP-370C Recombinant Cynomolgus FAP Protein, His-tagged HEK293 His
    Cynomolgus FAP-377CB Recombinant Cynomolgus FAP protein, His-Avi-tagged, Biotinylated HEK293 His-Avi
    Kit-1729 FAP Assay Kit N/A

    FAP involved in several pathways and played different roles in them. We selected most pathways FAP participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with FAP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein

    FAP has several biochemical functions, for example, dipeptidyl-peptidase activity, endopeptidase activity, integrin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FAP itself. We selected most functions FAP had, and list some proteins which have the same functions with FAP. You can find most of the proteins on our site.

    Function Related Protein
    dipeptidyl-peptidase activity FAP; PRCP; DPP3; NAALAD2; DPP4; DPEP1; DPEP2; DPEP3; DPP8; DPP7
    endopeptidase activity MMP9; Ren1; P4HB; AP1S2; PSEN2; PSMB2; FAP; KLK1B8; PSMA3; APH1B
    integrin binding EGFL6; THBS1; ACTN4; PTPN2; ADAM22; ANXA7; NF2; CIB2; ADAMTS13; SRC
    metalloendopeptidase activity OSGEPL1; MME; MMEL1; NRD1B; MMP12; MMP16; ADAMTS5; YME1L1B; MMP14B; ADAM5
    peptidase activity SPPL3; F9B; KLK1B8; TMPRSS7; C6AST3; BMP1A; CTSG; MCPT9; Shh; DESI1
    protease binding SRI; SERPINB6; TNFAIP3; HSPA6; BDKRB2; KIT; INSL3; TIMP2B; FADD; CST3
    protein binding MBL2; MAP2K7; LDLRAP1; KRTAP10-4; PRPF3; TKT; RNF24; SF3A2; VAV2; PPID
    protein dimerization activity MYCLA; BETA3; ZBED1; TFE3A; PIP; ARNTL1A; NEUROD6A; MYCL1; RIMKLB; TFAP2B
    protein homodimerization activity FGFR1OP; NFKB1; SLC14A2; ATIC; ABCG2; CDA; TSG101; CD226; IRAK1; TIMM10
    serine-type endopeptidase activity PRSS12; GZMM; F2; PCSK9; PRSS37; F10; CTSH; TPSG1; CLPP; PRSS45
    serine-type peptidase activity GZMB; KLK1B5; IMMP2L; EGFBP2; CMA1; MCPT1; MCPT2; KLK1B1; MCPT8; TMPRSS13B

    FAP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FAP here. Most of them are supplied by our site. Hope this information will be useful for your research of FAP.

    GCG; VIP; GHRH; NPY; GIP; PYY; NPPB; ADCYAP1; TAC1; b3xyc5_sollc

    Rabenhold, M; Steiniger, F; et al. Bispecific single-chain diabody-immunoliposomes targeting endoglin (CD105) and fibroblast activation protein (FAP) simultaneously. JOURNAL OF CONTROLLED RELEASE 201:56-67(2015).
    Polites, SF; Zarroug, AE; et al. Single-Incision Laparoscopic Ileal Pouch-Anal Anastomosis in Children-How Does It Compare to a Laparoscopic-Assisted Approach?. JOURNAL OF LAPAROENDOSCOPIC & ADVANCED SURGICAL TECHNIQUES 25:167-171(2015).

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