The protein encoded by this gene is a homodimeric integral membrane gelatinase belonging to the serine protease family. It is selectively expressed in reactive stromal fibroblasts of epithelial cancers, granulation tissue of healing wounds, and malignant cells of bone and soft tissue sarcomas. This protein is thought to be involved in the control of fibroblast growth or epithelial-mesenchymal interactions during development, tissue repair, and epithelial carcinogenesis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2014]
FAP involved in several pathways and played different roles in them. We selected most pathways FAP participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with FAP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
FAP has several biochemical functions, for example, dipeptidyl-peptidase activity, endopeptidase activity, integrin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FAP itself. We selected most functions FAP had, and list some proteins which have the same functions with FAP. You can find most of the proteins on our site.
FAP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FAP here. Most of them are supplied by our site. Hope this information will be useful for your research of FAP.
Rabenhold, M; Steiniger, F; et al. Bispecific single-chain diabody-immunoliposomes targeting endoglin (CD105) and fibroblast activation protein (FAP) simultaneously. JOURNAL OF CONTROLLED RELEASE 201:56-67(2015).
Polites, SF; Zarroug, AE; et al. Single-Incision Laparoscopic Ileal Pouch-Anal Anastomosis in Children-How Does It Compare to a Laparoscopic-Assisted Approach?. JOURNAL OF LAPAROENDOSCOPIC & ADVANCED SURGICAL TECHNIQUES 25:167-171(2015).
