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Recombinant Full Length Human FAP Protein, C-Flag-tagged

Cat.No. : FAP-589HFL
Product Overview : Recombinant Full Length Human FAP Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.
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Description : The protein encoded by this gene is a homodimeric integral membrane gelatinase belonging to the serine protease family. It is selectively expressed in reactive stromal fibroblasts of epithelial cancers, granulation tissue of healing wounds, and malignant cells of bone and soft tissue sarcomas. This protein is thought to be involved in the control of fibroblast growth or epithelial-mesenchymal interactions during development, tissue repair, and epithelial carcinogenesis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Source : Mammalian cells
Species : Human
Tag : Flag
Form : 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Mass : 87.5 kDa
AA Sequence : MKTWVKIVFGVATSAVLALLVMCIV LRPSRVHNSEENTMRALTLKDILNG TFSYKTFFPNWISGQEYLHQ SADNNIVLYNIETGQSYTILSNRTM KSVNASNYGLSPDRQFVYLESDYSK LWRYSYTATYYIYDLSNGEF VRGNELPRPIQYLCWSPVGSKLAYV YQNNIYLKQRPGDPPFQITFNGREN KIFNGIPDWVYEEEMLATKY ALWWSPNGKFLAYAEFNDTDIPVIA YSYYGDEQYPRTINIPYPKAGAKNP VVRIFIIDTTYPAYVGPQEV PVPAMIASSDYYFSWLTWVTDERVC LQWLKRVQNVSVLSICDFREDWQTW DCPKTQEHIEESRTGWAGGF FVSTPVFSYDAISYYKIFSDKDGYK HIHYIKDTVENAIQITSGKWEAINI FRVTQDSLFYSSNEFEEYPG RRNIYRISIGSYPPSKKCVTCHLRK ERCQYYTASFSDYAKYYALVCYGPG IPISTLHDGRTDQEIKILEE NKELENALKNIQLPKEEIKKLEVDE ITLWYKMILPPQFDRSKKYPLLIQV YGGPCSQSVRSVFAVNWISY LASKEGMVIALVDGRGTAFQGDKLL YAVYRKLGVYEVEDQITAVRKFIEM GFIDEKRIAIWGWSYGGYVS SLALASGTGLFKCGIAVAPVSSWEY YASVYTERFMGLPTKDDNLEHYKNS TVMARAEYFRNVDYLLIHGT
ADDNVHFQNSAQIAKALVNAQVDFQ AMWYSDQNHGLSGLSTNHLYTHMTH FLKQCFSLSDSGPTRTRPLEQKLIS EEDLAANDILDYKDDDDKV
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining.
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade.
Concentration : >50 ug/mL as determined by microplate BCA method.
Preparation : Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
Protein Families : Druggable Genome, Protease, Transmembrane
Gene Name : FAP fibroblast activation protein alpha [ Homo sapiens (human) ]
Official Symbol : FAP
Synonyms : FAPA; SIMP; DPPIV; FAPalpha
Gene ID : 2191
mRNA Refseq : NM_004460.5
Protein Refseq : NP_004451.2
MIM : 600403
UniProt ID : Q12884

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How does FAP contribute to immunosuppression in the tumor microenvironment? 04/18/2023

FAP can suppress the immune response by modulating the activity of certain immune cells, creating an immunosuppressive tumor microenvironment.

How can FAP expression be used as a prognostic marker in cancer patients? 02/03/2023

High levels of FAP expression in tumors have been associated with poor prognosis, making it a potential prognostic marker for certain cancers.

Are there ongoing clinical trials exploring FAP-targeted therapies? 05/04/2021

Yes, several clinical trials are investigating the safety and efficacy of FAP-targeted therapies in various cancer types.

Can FAP be utilized as a therapeutic target beyond cancer treatment? 11/19/2020

FAP-targeted therapies are being explored for conditions such as fibrotic diseases and rheumatoid arthritis, extending its potential clinical applications.

How is imaging technology utilized to detect FAP expression in tumors? 09/17/2018

Molecular imaging techniques, such as positron emission tomography (PET), can be employed to visualize FAP expression in tumors noninvasively.

Customer Reviews (3)

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Reviews
08/11/2020

    It enables accurate detection and quantification of FAP protein levels in samples, providing crucial insights into its expression, regulation, and potential functional changes under different experimental conditions.

    05/04/2020

      FAP protein is highly recommended for researchers due to its excellent performance in various assays, particularly in Western blotting (WB) experiments, and its applicability in protein electron microscopy structure analysis.

      01/02/2019

        FAP protein is highly recommended for researchers, as it demonstrates excellent performance in WB experiments and has proven useful in protein electron microscopy structure analysis.

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