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Recombinant Mouse Insulin-like Growth Factor Binding Protein 3

Cat. No.: Igfbp3-1750M
Product Overview: Recombinant Mouse Igfbp3 was fused to the human CD33 signal peptide. This chimeric protein was expressed inNSO cells.
Description: Insulin-like growth factor binding protein 3, also known as IGFBP3, is a member of the insulin-like growth factor binding protein (IGFBP) family that are cysteine-rich proteins that act as a carrier protein. The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors.
Molecular Weight: The predicted molecular weight of Recombinant Mouse IGFBP-3 is Mr 29;.4 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 40-50 kDa.
Source: NSO Cells.
State Of Matter: Lyophilized.
Purity: >95% by SDS Page and analyzed by silver stain.
Formulation: This recombinant protein was lyophilized from a 0.2 μm filtered solution in 35% acetonitrile (CH3CN) and 0.1% trifluoroacetic acid (TFA).
Endotoxin: <1.0 EU/µg as determined by the LAL method.
Biological Activity: The biological activity of Mouse IGFBP-3 was determined by its ability to inhibit the biological activity of rmIGF-II on MCF-7 cells (Karey, K.P. et al., 1988, Cancer Research 48:4083). The expected ED50 for this effect is typically 0.125 - 0.5 μg/ml in the presence of 30 ng/ml rmIGF-II.
Storage And Stability: This lyophilized protein is stable for six to twelve months when stored desiccated at -20℃ to -70℃. After aseptic reconstitution, this protein may be stored at 2℃ to 8℃ for one month or at -20℃ to -70℃ in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Gene Name: Igfbp3 insulin-like growth factor binding protein 3 [ Mus musculus ]
Synonyms: Igfbp3; insulin-like growth factor binding protein 3; IGFBP-3; IGgfbp3; AI649005; OTTMUSP00000005343
Gene ID: 16009
mRNA Refseq: NM_008343
Protein Refseq: NP_032369
UniProt ID: P47878
Chromosome Location: 11 A1; 11 1.35 cM
Pathway: p53 signaling pathway
Function: growth factor binding; insulin-like growth factor binding

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