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Recombinant Mouse Insulin-like Growth Factor Binding Protein 3

Cat. No. : Igfbp3-1750M
Product Overview : Recombinant Mouse Igfbp3 was fused to the human CD33 signal peptide. This chimeric protein was expressed inNSO cells.
Description : Insulin-like growth factor binding protein 3, also known as IGFBP3, is a member of the insulin-like growth factor binding protein (IGFBP) family that are cysteine-rich proteins that act as a carrier protein. The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors.
Molecular Weight : The predicted molecular weight of Recombinant Mouse IGFBP-3 is Mr 29;.4 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 40-50 kDa.
Source : NSO Cells.
State Of Matter : Lyophilized.
Purity : >95% by SDS Page and analyzed by silver stain.
Formulation : This recombinant protein was lyophilized from a 0.2 μm filtered solution in 35% acetonitrile (CH3CN) and 0.1% trifluoroacetic acid (TFA).
Endotoxin : <1.0 EU/µg as determined by the LAL method.
Biological Activity : The biological activity of Mouse IGFBP-3 was determined by its ability to inhibit the biological activity of rmIGF-II on MCF-7 cells (Karey, K.P. et al., 1988, Cancer Research 48:4083). The expected ED50 for this effect is typically 0.125 - 0.5 μg/ml in the presence of 30 ng/ml rmIGF-II.
Storage And Stability : This lyophilized protein is stable for six to twelve months when stored desiccated at -20℃ to -70℃. After aseptic reconstitution, this protein may be stored at 2℃ to 8℃ for one month or at -20℃ to -70℃ in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Gene Name : Igfbp3 insulin-like growth factor binding protein 3 [ Mus musculus ]
Synonyms : Igfbp3; insulin-like growth factor binding protein 3; IGFBP-3; IGgfbp3; AI649005; OTTMUSP00000005343
Gene ID : 16009
mRNA Refseq : NM_008343
Protein Refseq : NP_032369
UniProt ID : P47878
Chromosome Location : 11 A1; 11 1.35 cM
Pathway : p53 signaling pathway
Function : growth factor binding; insulin-like growth factor binding

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