Recombinant Mouse Interleukin 13 Receptor, Alpha 2

• Cat.No.: Il13ra2-1761M

Specification

• Cat. No.: Il13ra2-1761M
• Description: Interleukin 13 receptor alpha 2, also known as IL13RA2 and CD213A2, binds IL13 with high affinity, but lacks cytoplasmic domain, and does not appear to function as a signal mediator. IL13RA2 serves as a dominant negative inhibitor or a decoy receptor for IL-13. IL-13Ralpha2 is a promising target for ovarian cancer therapy, and the soluble form of IL-13R may be a possible surrogate marker for disease monitoring. IL13RA2 signaling during prolonged inflammation is also an important therapeutic target for the prevention of TGF-beta(1)-mediated fibrosis.
• Molecular Weight: The predicted molecular weight of Recombinant Mouse IL-13 Rα2 is Mr 63 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 85-90 kDa.
• Source: Mammalian cells
• State Of Matter: Lyophilized.
• Purity: >95% by SDS Page and analyzed by silver stain.
• Endotoxin: <1.0 EU/µg as determined by the LAL method.
• Storage And Stability: This lyophilized protein is stable for six to twelve months when stored desiccated at -20°Cto -70°C. After aseptic reconstitution, this protein may be stored at 2°Cto 8°Cfor one month or at -20°Cto -70°Cin a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.

Gene Information

• Gene Name: Il13ra2 interleukin 13 receptor, alpha 2 [ Mus musculus ]
• Synonyms: interleukin 13 receptor, alpha 2; CD213a2; OTTMUSP00000020481; Il13ra2
• Gene ID: 16165
• mRNA Refseq: NM_008356
• Protein Refseq: NP_032382
• UniProt ID: O88786
• Chromosome Location: X 63.0 cM
• Pathway: Jak-STAT signaling pathway
• Function: cytokine receptor activity; receptor activity