"TMPRSS2" Related Products

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Recombinant Human TMPRSS2

Cat.No.: TMPRSS2-30144TH
Product Overview: Recombinant fragment of Human TMPRSS2 with a proprietary tag; predicted mwt: 37.73 kDa.
Description: This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain. Serine proteases are known to be involved in many physiological and pathological processes. This gene was demonstrated to be up-regulated by androgenic hormones in prostate cancer cells and down-regulated in androgen-independent prostate cancer tissue. The protease domain of this protein is thought to be cleaved and secreted into cell media after autocleavage. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Protein length: 110 amino acids
Molecular Weight: 37.730kDa inclusive of tags
Source: Wheat germ
Tissue specificity: Expressed strongly in small intestine. Also expressed in prostate, colon, stomach and salivary gland.
Form: Liquid
Purity: Proprietary Purification
Storage buffer: pH: 8.00Constituents:0.31% Glutathione, 0.79% Tris HCl
Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequences of amino acids: GWGATEEKGKTSEVLNAAKVLLIETQRCNSRYVYDNLITPAMICAGFLQGNVDSCQGDSGGPLVTSKNNIWWLIGDTSWGSGCAKAYRPGVYGNVMVFTDWIYRQMRADG
Sequence Similarities: Belongs to the peptidase S1 family.Contains 1 LDL-receptor class A domain.Contains 1 peptidase S1 domain.Contains 1 SRCR domain.
Gene Name: TMPRSS2 transmembrane protease, serine 2 [ Homo sapiens ]
Official Symbol: TMPRSS2
Synonyms: TMPRSS2; transmembrane protease, serine 2; transmembrane protease serine 2; PRSS10;
Gene ID: 7113
mRNA Refseq: NM_005656
Protein Refseq: NP_005647
MIM: 602060
Uniprot ID: O15393
Chromosome Location: 21q22.3
Pathway: Coregulation of Androgen receptor activity, organism-specific biosystem; Influenza A, organism-specific biosystem; Influenza A, conserved biosystem; Regulation of Androgen receptor activity, organism-specific biosystem; Transcriptional misregulation in cancers, organism-specific biosystem;
Function: peptidase activity; scavenger receptor activity; serine-type endopeptidase activity; serine-type peptidase activity;

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