Cat. No. : |
WHSC1-429H |
Product Overview : |
Recombinant Human NSD2 (MMSET) (amino-acids 941-1240), with N-terminal GST tag expressed inE.Coliexpression system. MW = 62kDa. |
Description : |
Probable histone-lysine N-methyltransferase NSD2 is an enzyme that in humans is encoded by the WHSC1 gene. This gene encodes a protein that contains four domains present in other developmental proteins: a PWWP domain, an HMG box, a SET domain, and a PHD-type zinc finger. It is expressed ubiquitously in early development. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene maps to the 165 kb WHS critical region and has also been involved in the chromosomal translocation t(4;14)(p16.3;q32.3) in multiple myelomas. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. Some transcript variants are nonsense-mediated mRNA (NMD) decay candidates, hence not represented as reference sequences. |
Source : |
E.Coli. |
Purity : |
>65%. |
Application : |
Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. |
Formulated In : |
25 mM Tris-HCl, pH 8.0, 100 mM NaCl, 0.05% Tween-20, 30% glycerol, and 3 mM DTT. |
Stability : |
>6 months at –80°C. |