Recombinant Human Wolf-Hirschhorn Syndrome Candidate 1, GST-tagged
Cat.No. : | WHSC1-429H |
Product Overview : | Recombinant Human NSD2 (MMSET) (amino-acids 941-1240), with N-terminal GST tag expressed inE.Coliexpression system. MW = 62kDa. |
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Cat. No. : | WHSC1-429H |
Description : | Probable histone-lysine N-methyltransferase NSD2 is an enzyme that in humans is encoded by the WHSC1 gene. This gene encodes a protein that contains four domains present in other developmental proteins: a PWWP domain, an HMG box, a SET domain, and a PHD-type zinc finger. It is expressed ubiquitously in early development. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene maps to the 165 kb WHS critical region and has also been involved in the chromosomal translocation t(4;14)(p16.3;q32.3) in multiple myelomas. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. Some transcript variants are nonsense-mediated mRNA (NMD) decay candidates, hence not represented as reference sequences. |
Source : | E.Coli. |
Purity : | >65%. |
Application : | Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. |
Formulated In : | 25 mM Tris-HCl, pH 8.0, 100 mM NaCl, 0.05% Tween-20, 30% glycerol, and 3 mM DTT. |
Stability : | >6 months at –80°C. |
Protein length : | 941-1240 |
Gene Name : | EHMT2 euchromatic histone-lysine N-methyltransferase 2 [ Homo sapiens ] |
Synonyms : | WHSC1; Wolf-Hirschhorn syndrome candidate 1; IL5 promoter REII region-binding protein; OTTHUMP00000196943; Wolf-Hirschhorn syndrome candidate 1 protein; multiple myeloma SET domain containing protein type III; trithorax/ash1-related protein 5; WHS; NSD2; TRX5; MMSET; REIIBP; FLJ23286; KIAA1090; MGC176638; EC 2.1.1.43 |
Gene ID : | 7468 |
mRNA Refseq : | NM_001042424 |
Protein Refseq : | NP_001035889 |
MIM : | 602952 |
UniProt ID : | O96028 |
Chromosome Location : | 4p16.3 |
Pathway : | Lysine degradation |
Function : | DNA binding; histone-lysine N-methyltransferase activity; methyltransferase activity; protein binding; transferase activity; zinc ion binding |
Products Types
◆ Recombinant Protein | ||
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WHSC1-145H | Recombinant Human WHSC1 Protein | +Inquiry |
WHSC1-57H | Active Recombinant Human WHSC1, FLAG-tagged | +Inquiry |
WHSC1-18545M | Recombinant Mouse WHSC1 Protein | +Inquiry |
WHSC1-144H | Recombinant Human WHSC1 Protein, His-tagged | +Inquiry |
◆ Lysates | ||
WHSC1-1931HCL | Recombinant Human WHSC1 cell lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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