Recombinant Human C-src Tyrosine Kinase, GST-tagged, Active

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Recombinant Human C-src Tyrosine Kinase, GST-tagged, Active

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Cat. No. : CSK-288H
Product Overview : Recombinant full-length human CSK was expressed by baculovirus inSf9 insect cellsusing a N-terminal GST tag. MW= 78 kDa.
Description : CSK is a cytoplasmic tyrosine kinase that has been shown to downregulate the tyrosine kinase activity of the c-src through tyrosine phosphorylation of the c-src carboxy terminus. A yeast 2-hybrid system has been used to identify proteins associated with CSK. The Src homology-3 (SH3) domain of CSK associates with a proline-rich region of PEP, a protein-tyrosine phosphatase expressed in hemopoietic cells.
Source : Sf9 insect cellsusing baculovirus.
Sequence : Full-lengt h.
Applications : Kinase Assay, Western Blot.
Storage And Stability : Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Gene Name : CSK c-src tyrosine kinase [ Homo sapiens ]
Synonyms : CSK; c-src tyrosine kinase; MGC117393; EC 2.7.10.2
Gene ID : 1445
mRNA Refseq : NM_001127190
Protein Refseq : NP_001120662
MIM : 124095
UniProt ID : P41240
Chromosome Location : 15q23-q25
Pathway : Chemokine signaling pathway; Epithelial cell signaling in Helicobacter pylori infection; Neurotrophin signaling pathway; Regulation of actin cytoskeleton; Integrin cell surface interactions; Signaling in Immune system; Signaling by EGFR
Function : ATP binding; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; protein C-terminus binding; transferase activity
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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