Cat. No. :	CSK-288H
Product Overview :	Recombinant full-length human CSK was expressed by baculovirus inSf9 insect cellsusing a N-terminal GST tag. MW= 78 kDa.
Description :	CSK is a cytoplasmic tyrosine kinase that has been shown to downregulate the tyrosine kinase activity of the c-src through tyrosine phosphorylation of the c-src carboxy terminus. A yeast 2-hybrid system has been used to identify proteins associated with CSK. The Src homology-3 (SH3) domain of CSK associates with a proline-rich region of PEP, a protein-tyrosine phosphatase expressed in hemopoietic cells.
Source :	Sf9 insect cellsusing baculovirus.
Sequence :	Full-length.
Applications :	Kinase Assay, Western Blot.
Storage And Stability :	Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Gene Name :	CSK c-src tyrosine kinase [ Homo sapiens ]
Synonyms :	CSK; c-src tyrosine kinase; MGC117393; EC 2.7.10.2
Gene ID :	1445
mRNA Refseq :	NM_001127190
Protein Refseq :	NP_001120662
MIM :	124095
UniProt ID :	P41240
Chromosome Location :	15q23-q25
Pathway :	Chemokine signaling pathway; Epithelial cell signaling in Helicobacter pylori infection; Neurotrophin signaling pathway; Regulation of actin cytoskeleton; Integrin cell surface interactions; Signaling in Immune system; Signaling by EGFR
Function :	ATP binding; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; protein C-terminus binding; transferase activity

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