"NEIL2" Related Products

Recombinant Human Nei Endonuclease VIII-like 2 (E. coli)

Cat. No.: NEIL2-586H
Product Overview: Recombinant human NEIL2 was expressed in and purified fromE. coli.
Description: NEIL2 is a DNA glycosylase involved in base excision repair of oxidative DNA damage. It is a member of the Fpg/Nei/NEIL family of bi-functional DNA glycosylases. Following its glycosylase action, NEIL2 catalyzes sequential β-elimination and δ-elimination reactions via its associated AP lyase. This results in a one-nucleotide gap in DNA containing a 3' phosphate group. A phosphatase is needed to remove the 3'phosphate group before DNA repair synthesis can occur.
Source: E. coli.
Purity: Apparent homogeneity by SDS-PAGE and Coomassie blue staining.
Formulation: 20 mM Tris-HCl, pH 7.5, 300 mM NaCl, 10% glycerol.
Storage: Store at -70°C. Aliquot to avoid repeated freezing and thawing.
Gene Name: NEIL2 nei endonuclease VIII-like 2 (E. coli) [ Homo sapiens ]
Synonyms: NEIL2; nei endonuclease VIII-like 2 (E. coli); NEH2; NEI2; MGC2832; MGC4505; FLJ31644; nei like 2; EC; DNA glycosylase/AP lyase Neil2; DNA-(apurinic or apyrimidinic site) lyase Neil2; Nei-like protein 2; Nei homolog 2; Nei-like 2
Gene ID: 252969
mRNA Refseq: NM_001135746
Protein Refseq: NP_001129218
MIM: 608933
UniProt ID: Q969S2
Chromosome Location: 8p23.1
Pathway: Base excision repair
Function: DNA-(apurinic or apyrimidinic site) lyase activity; damaged DNA binding; hydrolase activity, hydrolyzing N-glycosyl compounds; lyase activity; metal ion binding; microtubule binding; zinc ion binding

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