"PPP1R1A" Related Products


Recombinant Human PPP1R1A, GST-tagged

Cat. No. : PPP1R1A-2049H
Product Overview : Recombinant human Inhibitor-1 with GST tag is a 171-amino acid protein with an average molecular weight of 18.9 kDa. It was expressed inE. coli,50kDa.
Description : It is a specific inhibitor of Type-1 protein serine/threonine phosphatases. The IC50 for inhibition of PP1 is ~ 1 nm. The selectivity and potency of inhibitor-1 are conferred by its N-terminal sequence KIQF and its activation by phosphorylation at Thr35 catalyzed by protein kinase A. Dephosphorylation and inactivation can be carried out in the presence of Ca2+ by PP2B.
Source : E. coli.
Purity : > 90% by SDS-PAGE.
Supplied : 1 mg in 50 ml 50 mM Tris-HCl pH 7.0 buffer containing 14 mM b-mercaptoethanol, 1 mM benzamidi 0.1 mM phenylmethanesulfonyl fluoride, 1 mM EDTA and 10% glycerol.
Storage : Maintain preparations in aliquots at -70 °C. Avoid repeated thawing.
Gene Name : PPP1R1A protein phosphatase 1, regulatory (inhibitor) subunit 1A [ Homo sapiens ]
Synonyms : PPP1R1A; protein phosphatase 1, regulatory (inhibitor) subunit 1A; PPP1R1A protein phosphatase 1, regulatory (inhibitor) subunit 1A; I-1; IPP-1; IPP1; inhibitor-1; protein phosphatase inhibitor-1; Protein phosphatase inhibitor 1
Gene ID : 5502
mRNA Refseq : NM_006741
Protein Refseq : NP_006732
MIM : 613246
UniProt ID : Q13522
Chromosome Location : 15q15.1-q15.2
Pathway : Long-term potentiation
Function : protein binding; protein serine/threonine phosphatase inhibitor activity

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