Recombinant Human PPP1R1A, GST-tagged


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Recombinant Human PPP1R1A, GST-tagged

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Cat. No. : PPP1R1A-2049H
Product Overview : Recombinant human Inhibitor-1 with GST tag is a 171-amino acid protein with an average molecular weight of 18.9 kDa. It was expressed inE. coli,50kDa.
Description : It is a specific inhibitor of Type-1 protein serine/threonine phosphatases. The IC50 for inhibition of PP1 is ~ 1 nm. The selectivity and potency of inhibitor-1 are conferred by its N-terminal sequence KIQF and its activation by phosphorylation at Thr35 catalyzed by protein kinase A. Dephosphorylation and inactivation can be carried out in the presence of Ca2+ by PP2B.
Source : E. coli.
Purity : > 90% by SDS-PAGE.
Supplied : 1 mg in 50 ml 50 mM Tris-HCl pH 7.0 buffer containing 14 mM b-mercaptoethanol, 1 mM benzamidi 0.1 mM phenylmethanesulfonyl fluoride, 1 mM EDTA and 10% glycerol.
Storage : Maintain preparations in aliquots at -70 °C. Avoid repeated thawing.
Gene Name : PPP1R1A protein phosphatase 1, regulatory (inhibitor) subunit 1A [ Homo sapiens ]
Synonyms : PPP1R1A; protein phosphatase 1, regulatory (inhibitor) subunit 1A; PPP1R1A protein phosphatase 1, regulatory (inhibitor) subunit 1A; I-1; IPP-1; IPP1; inhibitor-1; protein phosphatase inhibitor-1; Protein phosphatase inhibitor 1
Gene ID : 5502
mRNA Refseq : NM_006741
Protein Refseq : NP_006732
MIM : 613246
UniProt ID : Q13522
Chromosome Location : 15q15.1-q15.2
Pathway : Long-term potentiation
Function : protein binding; protein serine/threonine phosphatase inhibitor activity
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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