Recombinant Human Arachidonate 5-lipoxygenase


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Recombinant Human Arachidonate 5-lipoxygenase

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Cat. No. : ALOX5-696H
Product Overview : Recombinant Human Arachidonate 5-lipoxygenase isolated from baculovirus overexpression system inSf21 cells.
Description : This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants have been observed, but their full-length nature has not been determined.
Source : Sf21.
Concentration : 538 units/ ml, 14.4 mg/ml protein.
Form : Liquid in 50 mM Tris-HCl buffer containing EGTA, pH8.0.
Storage : -700C. Upon initial thaw, aliquot ino single-use volumes and freeze (-700C).
Gene Name : ALOX5 arachidonate 5-lipoxygenase [ Homo sapiens ]
Synonyms : ALOX5; arachidonate 5-lipoxygenase;5-LO; 5LPG; LOG5; 5-LOX; MGC163204; arachidonate 5-lipoxygenase; 5-lipoxygenase; leukotriene A4 synthase; arachidonic acid 5-lipoxygenase; EC
Gene ID : 240
mRNA Refseq : NM_000698
Protein Refseq : NP_000689
MIM : 152390
UniProt ID : P09917
Chromosome Location : 10q11.2
Pathway : Arachidonic acid metabolism; Metabolic pathways
Function : arachidonate 5-lipoxygenase activity; iron ion binding; lipoxygenase activity; oxidoreductase activity; protein binding
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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