Recombinant Human Cathepsin L2, His-tagged


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Recombinant Human Cathepsin L2, His-tagged

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Cat. No. : CTSL2-751H
Product Overview : Recombinant human procathepsin V (amino acids 18-334) was fused at the N-terminus to a CD33 signal sequence (amino acids 1-16) and at the C-terminus to a His•Tag sequence and expressed inNSOcells. MW =38.7 kDa.
Description : Cathepsin L2, also known as CTSL2, Cathepsin V, CATL2, and CTSV, is a member of the peptidase C1 family. It is predominantly expressed in the thymus and testis. Cathepsin V is also expressed in corneal epithelium, and to a lesser extent in conjuctival epithelium and skin. Cathepsin V is a lysosomal cysteine proteinase that may play an important role in corneal physiology. It has about 75% protein sequence identity to murine cathepsin L. The fold of this enzyme is similar to the fold adopted by other members of the papain superfamily of cysteine proteases. Cathepsins K and S are papain-like cysteine proteases with known elastolytic activities, and both enzymes have been identified in macrophages present in plaque areas of diseased blood vessels. Cathepsin V is the third elastolytic cysteine protease which exhibits the most potent elastase activity yet described among human proteases and that Cathepsin V is present in atherosclerotic plaque specimens. Increase of cathepsins V and K activities may accelerate the destruction of the elastin matrix in diseased arteries.
Source : Mammalian cells
Purity : ≥95% by SDS-PAGE.
Form : Frozen liquid. In 800 mM NaCl, 25 mM sodium acetate, 0.8 M NaCl, pH 5.0. Please refer to vial label for lot-specific concentration.
Endotoxins : ≤1.0 EU/µg Cathepsin V.
Specific Activity : ≥300 units/µg.
Unit Definition : One unit is defined as the amount of enzyme that will cleave 1 pmol the fluorescent substrate Z-LR-AMC per min at 25°C, pH 5.5.
Toxicity : Standard Handling (MSDS available upon request).
Storage : ≤-70℃. Avoid freeze/thaw. To activate rhCathepsin V, pre-incubate it at 20 µg/ml in 25 mM NaOAc, 100 mM NaCl, 5 mM DTT, pH 5.5 at room temperature. Following initial thaw aliquot and freeze (-70℃).
PDB rendering based on 1fh0. :

Gene Name : CTSL2 cathepsin L2 [ Homo sapiens ]
Synonyms : CTSL2; cathepsin L2; CTSU; CTSV; CATL2; MGC125957; EC; Cathepsin L2; Cathepsin V; Cathepsin U; UNQ268/PRO305
Gene ID : 1515
mRNA Refseq : NM_001333
Protein Refseq : NP_001324
MIM : 603308
UniProt ID : O60911
Chromosome Location : 9q22.2
Pathway : Lysosome
Function : cysteine-type endopeptidase activity; peptidase activity; protein binding
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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