Human IDO1 Cell-Based Assay Kit
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Cat.No. : | Kit-1754 |
Product Overview : | L-tryptophan (L-Trp) is an essential amino acid necessary for protein synthesis in mammalian cells and the L-Trp to kynurenine (Kyn) pathway is firmly established as a key regulator of innate and adaptive immunity. Catabolism of L-Trp to Kyn maintains an immunosuppressive microenvironment by starving immune cells of L-Trp and releasing degradation products of LTrp that have immunosuppressive functions. Indoleamine 2,3-dioxygenases (IDO1 & IDO2), two of the rate limiting enzymes in this pathway, are upregulated in many tumors, providing cancer cells with an avenue for immune evasion. |
Size : | 100 reactions |
Applications : | Screen for inhibitors of hIDO1 enzyme in a cellular context. Note: The expression vector is designed for use in transient transfection protocols. It is NOT SUITABLE for transformation and amplification in bacteria. |
Storage : | Stable at least 6 months from date of receipt, when stored as directed. Kit components require different storage conditions. Be sure to store each component at the proper temperature upon arrival. |
◆ Recombinant Protein
IDO1-2077M | Recombinant Mouse IDO1 Protein (1-407 aa), His-tagged | +Inquiry |
IDO1-3829H | Recombinant Human IDO1 protein, GST-tagged | +Inquiry |
Ido1-2126M | Recombinant Mouse Indoleamine 2,3-dioxygenase 1, His-tagged | +Inquiry |
IDO1-1419H | Recombinant Human IDO1 Protein (1-403 aa), His-tagged | +Inquiry |
IDO1-085H | Recombinant Human IDO1 Protein, MYC/DDK-tagged, C13 and N15-labeled | +Inquiry |
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◆ Lysates
IDO1-5300HCL | Recombinant Human IDO1 293 Cell Lysate | +Inquiry |
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◆ Assay kits
Kit-1763 | IDO1 Inhibitor Mechanism of Action Assay Kit | +Inquiry |
Kit-1758 | Human IDO1 Inhibitor Screening Assay Kit (384) | +Inquiry |
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