Human IDO1 Fluorogenic Inhibitor Screening Assay Kit
Cat.No. : | Kit-1755 |
Product Overview : | L-tryptophan (L-Trp) is an essential amino acid necessary for protein synthesis in mammalian cells and the L-Trp to kynurenine (Kyn) pathway is firmly established as a key regulator of innate and adaptive immunity. Catabolism of L-Trp to Kyn maintains an immunosuppressive microenvironment by starving immune cells of L-Trp and releasing degradation products of L-Trp that have immunosuppressive functions. Indoleamine 2,3- dioxygenases (IDO1 & IDO2), two of the rate limiting enzymes in this pathway, are upregulated in many tumors, providing cancer cells with an avenue for immune evasion. |
- Specification
- Gene Information
- Related Products
Size : | 96 reactions |
Applications : | Useful for the study of IDO1 enzymology, inhibitor screening, and selectivity profiling. |
Storage : | Stable at least 6 months from date of receipt, when stored as directed. Kit components require different storage conditions. Be sure to store each component at the proper temperature upon arrival |
Products Types
◆ Recombinant Protein | ||
IDO1-01H | Recombinant Human IDO1 Protein, His/Avi-tagged | +Inquiry |
IDO1-3829H | Recombinant Human IDO1 protein, GST-tagged | +Inquiry |
IDO1-2645R | Recombinant Rat IDO1 Protein, His (Fc)-Avi-tagged | +Inquiry |
Ido1-1213M | Recombinant Mouse Ido1 Protein, MYC/DDK-tagged | +Inquiry |
IDO1-1138H | Recombinant Human IDO1 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
IDO1-5300HCL | Recombinant Human IDO1 293 Cell Lysate | +Inquiry |
◆ Assay kits | ||
Kit-2211 | Indoleamine 2,3-Dioxygenase 1 Activity Assay Kit | +Inquiry |
Kit-2388 | Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitor Screening Kit | +Inquiry |
Kit-1763 | IDO1 Inhibitor Mechanism of Action Assay Kit | +Inquiry |
Kit-1757 | Human IDO1 Inhibitor Screening Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
0
Inquiry Basket