Species : |
Human |
Source : |
E.coli |
Tag : |
Non |
Description : |
The protein encoded by this gene is highly homologous to alpha-synuclein. These proteins are abundantly expressed in the brain and putatively inhibit phospholipase D2 selectively. The encoded protein, which may play a role in neuronal plasticity, is abundant in neurofibrillary lesions of patients with Alzheimer disease. This protein has been shown to be highly expressed in the substantia nigra of the brain, a region of neuronal degeneration in patients with Parkinson disease; however, no direct relation to Parkinson disease has been established. Two transcript variants encoding the same protein have been found for this gene. |
Tissue specificity : |
Expressed predominantly in brain; concentrated in presynaptic nerve terminals. |
Form : |
Liquid |
Purity : |
>95% by SDS-PAGE |
Storage buffer : |
Preservative: NoneConstituents: 0.1M Sodium chloride, 20mM Tris HCl, 1mM Magnesium chloride, pH 7.5 |
Storage : |
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. |
Sequences of amino acids : |
MDVFMKGLSM AKEGVVAAAE KTKQGVTEAA EKTKEGVLYV GSKTREGVVQGVASVAEKTK EQASHLGGAV FSGAGNIAAA TGLVKREEFP TDLKPEEVAQEAAEEPLIEP LMEPEGESYE DPPQEEYQEY EPEA |
Sequence Similarities : |
Belongs to the synuclein family. |
Full Length : |
Full L. |