Native Mouse MMP2

Cat.No. : MMP2-8455M
Product Overview : LPA was purified from Mouse Fibroblast.
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Description : The progelatinase A, a member of the matrix metalloproteinase (MMP) family, has been isolated from macrophages and fibroblasts. Gelatinase A hydrolyses several components of the extracellular matrix, e.g. the collagen types IV, V and XI and gelatin. Progelatinase A complexed via their C-terminal domain with TIMP-2 was isolated from culture media of different cell types. This complex shows both properties of its constituents: Like TIMP-2 it inhibits active matrix metalloproteinases and like gelatinase it shows proteolytic activity after activation with APMA (4-aminophenylmercury acetate). However, its proteolytic activity is less than 10% of that of gelatinase A not complexed with TIMP-2. In contrast to the other MMPs the progelatinase A cannot be activated by the serine proteinase trypsin. Until quite recently a potential natural activator that can transform latent progelatinase A into the active form was unknown. It was shown that the catalytic domain of the membrane type 2-matrix metalloproteinase activates progelatinase A as well as the progelatinase A / TIMP-2 complex, by cleaving the 72 kDa progelatinase A to yield 67 kDa gelatinase A, which is than transformed into 62 kDa gelatinase A. The 62 kDa form is about twice as active as the 67 kDa form towards the Dnp-pepitde (Masui et al.). No significant difference in activity was found between free and complexed gelatinase A forms
Source : Mouse Fibroblast
Species : Mouse
Form : In 50 mM Tris-HCl, pH 7; 200 mM NaCl; 5 mM CaCl2; 1 μM ZnCl2; 0.05% Brij 35; 0,05% NaN3
Molecular Mass : 40/42 kDa
Purity : ≥0% by SDS - PAGE
Storage : Lyophilized hUK is best stored desiccated below 8°C. Reconstituted hUK can be stored at 4°C for 2-7 days. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid freeze-thaw cycles.
Shipping : Dry Ice
Gene Name : Mmp2 matrix metallopeptidase 2 [ Mus musculus ]
Official Symbol : MMP2
Synonyms : MMP2; matrix metallopeptidase 2; 72 kDa type IV collagenase; gelatinase A; 72kD gelatinase; 72kDa gelatinase; 72 kDa gelatinase; 72kD type IV collagenase; 72kDa type IV collagenase; matrix metalloproteinase 2; matrix metalloproteinase-2; GelA; Clg4a; MMP-
Gene ID : 17390
mRNA Refseq : NM_008610
Protein Refseq : NP_032636
Pathway : Bladder cancer, organism-specific biosystem; Bladder cancer, conserved biosystem; Diabetes pathways, organism-specific biosystem; Disease, organism-specific biosystem; GnRH signaling pathway, organism-specific biosystem; GnRH signaling pathway, conserved biosystem; IL-3 Signaling Pathway, organism-specific biosystem;
Function : fibronectin binding; hydrolase activity; metal ion binding; metalloendopeptidase activity; metallopeptidase activity; peptidase activity; zinc ion binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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06/19/2021

    The solubility and ion exchange ability are very good, which is convenient for subsequent experimental treatment and purification.

    05/13/2021

      Kinetic parameters such as enzymatic reaction rate and binding affinity were tested in the early stage, and it was found that the protein performed well.

      03/16/2021

        MMP2 products undergo strict quality control to ensure the consistency and stability of each batch.

        Q&As (6)

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        How to regulate the activity of MMP2 in tumor therapy? 10/20/2022

        The activity of MMP2 is regulated by inhibitors and antibodies against it to inhibit tumor metastasis and invasion.

        How is MMP2 related to metastases that promote disease progression? 05/04/2022

        MMP2 interacts with some transfer factors, such as VEGF and EGF, to promote tumor metastasis and invasion.

        What are the application prospects of MMP2 inhibitors? 02/20/2022

        Inhibitors of MMP2 can be used as potential drug targets for the treatment of tumors, cardiovascular diseases and other related diseases.

        Does MMP2 interact with the tumor microenvironment? 09/15/2021

        MMP2 interacts with tumor cells, immune cells, blood vessels, etc. in the tumor microenvironment to affect tumor progression and treatment effect.

        What is the role of MMP2 in embryonic development? 10/18/2020

        It is involved in important processes such as morphogenesis, organ development and intraembryonic lymphatic vessel formation during embryonic development.

        What are the effects of MMP2 mutations in human disease? 10/13/2020

        Mutations in MMP2 may affect its protein structure and function, leading to the occurrence and progression of related diseases.

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