PCSK9[Biotinylated]-LDLR Binding Assay Kit
Cat.No. : | Kit-1807 |
Product Overview : | PCSK9 is a crucial player in the regulation of plasma cholesterol homeostasis. It binds to the ectodomain of hepatic low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their degradation. Acts via a non-proteolytic mechanism to enhance the degradation of the hepatic LDLR through a clathrin LDLRAP1/ARH-mediated pathway. May prevent the recycling of LDLR from endosomes to the cell surface or direct it to lysosomes for degradation. |
- Specification
- Gene Information
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Size : | 96 reactions |
Applications : | Great for screening small molecules and antibodies that inhibit the binding of PCSK9 to LDLR ectodomain. |
Storage : | Mixed storage conditions. Stable at least 12 months from date of receipt, when stored as directed |
Products Types
◆ Recombinant Protein | ||
Pcsk9-6566M | Recombinant Mouse Pcsk9 Protein, His (Fc)-Avi-tagged | +Inquiry |
PCSK9-413R | Recombinant Rat PCSK9 Protein, His-tagged | +Inquiry |
Pcsk9-265M | Recombinant Mouse PCSK9 Protein, His-tagged(C-ter) | +Inquiry |
PCSK9-3152R | Recombinant Rhesus Macaque PCSK9 Protein, His (Fc)-Avi-tagged | +Inquiry |
PCSK9-03H | Active Recombinant Human PCSK9 Protein, His-tagged | +Inquiry |
◆ Lysates | ||
PCSK9-2875HCL | Recombinant Human PCSK9 cell lysate | +Inquiry |
PCSK9-2306RCL | Recombinant Rat PCSK9 cell lysate | +Inquiry |
PCSK9-2775RCL | Recombinant Rhesus PCSK9 cell lysate | +Inquiry |
◆ Assay kits | ||
Kit-1806 | PCSK9(D374T)-LDLR TR-FRET Assay Kit | +Inquiry |
Kit-1808 | PCSK9-LDLR TR-FRET Assay Kit | +Inquiry |
Kit-0666 | PCSK9-LDLR in vitro Binding Assay Kit | +Inquiry |
Kit-0665 | PCSK9-BIRC2 in vitro Binding Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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